Figure 3

Loss of LKB1 results in reduced lung metastatic burden. The percentage of mice within each cohort that developed spontaneous lung metastases, the number of lung metastases, the average lesion size and the percentage lesion area present per total lung area were determined at necropsy on mice subjected to mammary fat pad injection with NIC-FF and NIC LKB1 KD cells (n = 10 mice per group) (A-D) or mice subjected to tail vein injections with NIC-FF and NIC LKB1 KD cells (n = 10 mice per group) (E-H). *, P< 0.05; **, P< 0.01; ***, P< 0.001. n.s., not significant.