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  1. Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent para...

    Authors: Lucas B Sullivan and Navdeep S Chandel
    Citation: Cancer & Metabolism 2014 2:17
  2. Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…
    Citation: Cancer & Metabolism 2014 2:24

    The original article was published in Cancer & Metabolism 2014 2:13

  3. Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug ...

    Authors: Yuting Sun, Anneleen Daemen, Georgia Hatzivassiliou, David Arnott, Catherine Wilson, Guanglei Zhuang, Min Gao, Peter Liu, Aaron Boudreau, Leisa Johnson and Jeff Settleman
    Citation: Cancer & Metabolism 2014 2:20
  4. It is a well-established scientific observation that mammalian cells contain fidelity proteins that appear to protect against and adapt to various forms of endogenous and exogenous cellular conditions. Loss of...

    Authors: Yueming Zhu, Yufan Yan, Daniel R Principe, Xianghui Zou, Athanassios Vassilopoulos and David Gius
    Citation: Cancer & Metabolism 2014 2:15
  5. In order to solve a jigsaw puzzle, one must first have the complete picture to logically connect the pieces. However, in cancer biology, we are still gaining an understanding of all the signaling pathways that...

    Authors: Rana Elkholi, Thibaud T Renault, Madhavika N Serasinghe and Jerry E Chipuk
    Citation: Cancer & Metabolism 2014 2:16
  6. Macroautophagy (autophagy hereafter) captures and degrades intracellular proteins and organelles in lysosomes as a quality control mechanism and recycles their components to sustain survival in starvation. Cel...

    Authors: Eileen White
    Citation: Cancer & Metabolism 2014 2:14
  7. Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known...

    Authors: Surendra K Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, Iraklis I Pipinos, Robert Powers, Fang Yu and Pankaj K Singh
    Citation: Cancer & Metabolism 2014 2:18

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:23

  8. Metformin is widely used in the treatment of diabetes, and there is interest in ‘repurposing’ the drug for cancer prevention or treatment. However, the mechanism underlying the metabolic effects of metformin r...

    Authors: Sylvia Andrzejewski, Simon-Pierre Gravel, Michael Pollak and Julie St-Pierre
    Citation: Cancer & Metabolism 2014 2:12
  9. Loss of the endosulfatase HSulf-1 is common in ovarian cancer, upregulates heparin binding growth factor signaling and potentiates tumorigenesis and angiogenesis. However, metabolic differences between isogeni...

    Authors: Debarshi Roy, Susmita Mondal, Chen Wang, Xiaoping He, Ashwani Khurana, Shailendra Giri, Robert Hoffmann, Deok-Beom Jung, Sung H Kim, Eduardo N Chini, Juliana Camacho Periera, Clifford D Folmes, Andrea Mariani, Sean C Dowdy, Jamie N Bakkum-Gamez, Shaun M Riska…
    Citation: Cancer & Metabolism 2014 2:13

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:24

  10. Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute two important characteristics of carcinoma progression toward invasive cancer. Despite an extensive characterization of ...

    Authors: Mark Masin, Jessica Vazquez, Simona Rossi, Svenja Groeneveld, Natasha Samson, Petra C Schwalie, Bart Deplancke, Laura E Frawley, Jérôme Gouttenoire, Darius Moradpour, Trudy G Oliver and Etienne Meylan
    Citation: Cancer & Metabolism 2014 2:11
  11. Cancer is a heterogeneous set of diseases characterized by different molecular and cellular features. Over the past decades, researchers have attempted to grasp the complexity of cancer by mapping the genetic ...

    Authors: Edoardo Gaude and Christian Frezza
    Citation: Cancer & Metabolism 2014 2:10
  12. Cellular metabolism is highly dynamic and continuously adjusts to the physiological program of the cell. The regulation of metabolism appears at all biological levels: (post-) transcriptional, (post-) translat...

    Authors: Matthias Pietzke, Christin Zasada, Susann Mudrich and Stefan Kempa
    Citation: Cancer & Metabolism 2014 2:9
  13. Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is...

    Authors: Tamir Epstein, Liping Xu, Robert J Gillies and Robert A Gatenby
    Citation: Cancer & Metabolism 2014 2:7

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