Variable Median (range) | L-G6pc+/+ shSCR | L-G6pc+/+ shChREBP | L-G6pc−/− shSCR | L-G6pc−/− shChREBP |
---|---|---|---|---|
Body weight (g) | 29.3 (27.8–31.6) | 27.4 (25.6–29.2) | 29.1 (25.3–30.5) | 27.6 (21.1–32.8) |
Liver weight (g) | 1.27 (1.14–1.75) | 1.89 (1.28–2.10)** | 2.06 (1.17–2.39)*** | 5.72 (2.15–9.20)***^^^### |
Blood glucose (mmol/L) | 11.1 (7.7–14.2) | 10.4 (8.8–14.2) | 9.2 (4.9–13.1) | 4.9 (1.1–11.5)***^^# |
Liver | ||||
  G6P (µmol/g liver) | 0.47 (0.29–0.66) | 0.53 (0.31–0.63) | 1.38 (0.77–3.04)***^^^ | 1.71 (1.28–3.60)***^^^ |
  G6P (µmol/liver) | 0.65 (0.41–0.81) | 1.00 (0.49–1.19)* | 1.99 (1.50–6.26)***^^^ | 11.58 (2.75–19.15)***^^^## |
  Glycogen (mg/liver) | 98 (68–136) | 163 (93–224)* | 190 (71–234)** | 915 (151–1926)***^^^## |
  Triglycerides (µmol/liver) | 8.7 (0.1–23.9) | 79.3 (7.6–106.1)*** | 60.8 (22.3–80.7)** | 50.3 (0.6–238.9)** |
  Free cholesterol (µmol/g liver) | 3.94 (2.70–4.54) | 3.36 (3.23–3.91)* | 3.46 (2.97–4.02) | 2.20 (1.13–5.43)** |
  Free cholesterol (µmol/liver) | 5.08 (3.74–6.44) | 6.31 (4.88–7.01) | 6.92 (4.71–8.23)** | 11.73 (10.23–14.48)***^^^### |
  Cholesteryl-esters (µmol/g liver) | 0.68 (0.02–0.94) | 1.80 (0.57–3.02)** | 1.85 (1.16–3.03)** | 1.23 (0.10–5.47)* |
  Cholesteryl-esters (µmol/liver) | 0.83 (0.03–1.65) | 3.57 (0.73–4.78)** | 3.23 (2.26–5.11)*** | 7.73 (0.79–11.77)*** |
  Total cholesterol (µmol/g liver) | 4.45 (2.91–5.27) | 5.13 (3.98–6.51) | 5.27 (4.14–6.68) | 3.36 (1.33–10.90) |
  Total cholesterol (µmol/liver) | 5.87 (4.02–7.93) | 10.01 (5.73–10.73)** | 9.93 (6.97–13.15)*** | 20.06 (11.03–24.79)***^^^### |
  Protein (mg/liver) | 300 (241–401) | 381 (290–412) | 430 (229–481)** | 656 (394–821)***^^^## |
Plasma | ||||
  Lactate (mmol/L) | 3.94 (3.46–5.83) | 4.72 (3.53–6.09) | 5.62 (4.02–7.17) | 5.03 (2.65–6.38) |
  Total ketone bodies (mmol/L) | 0.072 (0.055–0.112) | 0.087 (0.055–0.165) | 0.082 (0.059–0.197) | 0.123 (0.090–0.224)**^# |
  3HB (mmol/L) | 0.069 (0.051–0.109) | 0.084 (0.052–0.161) | 0.079 (0.056–0.192) | 0.121 (0.087–0.219)**^# |
  ACA (mmol/L) | 0.003 (0.002–0.007) | 0.004 (0.003–0.007) | 0.003 (0.002–0.005) | 0.003 (0.000–0.005) |
  FFA (µmol/L) | 153 (96–259) | 166 (129–254) | 224 (69–306) | 167 (97–409) |