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Table 2 General data of prolonged shSCR- and shChREBP-treated L-G6pc+/+ and L-G6pc−/− mice

From: Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Variable

Median (range)

L-G6pc+/+ shSCR

L-G6pc+/+ shChREBP

L-G6pc−/− shSCR

L-G6pc−/− shChREBP

Body weight (g)

29.3 (27.8–31.6)

27.4 (25.6–29.2)

29.1 (25.3–30.5)

27.6 (21.1–32.8)

Liver weight (g)

1.27 (1.14–1.75)

1.89 (1.28–2.10)**

2.06 (1.17–2.39)***

5.72 (2.15–9.20)***^^^###

Blood glucose (mmol/L)

11.1 (7.7–14.2)

10.4 (8.8–14.2)

9.2 (4.9–13.1)

4.9 (1.1–11.5)***^^#

Liver

  G6P (µmol/g liver)

0.47 (0.29–0.66)

0.53 (0.31–0.63)

1.38 (0.77–3.04)***^^^

1.71 (1.28–3.60)***^^^

  G6P (µmol/liver)

0.65 (0.41–0.81)

1.00 (0.49–1.19)*

1.99 (1.50–6.26)***^^^

11.58 (2.75–19.15)***^^^##

  Glycogen (mg/liver)

98 (68–136)

163 (93–224)*

190 (71–234)**

915 (151–1926)***^^^##

  Triglycerides (µmol/liver)

8.7 (0.1–23.9)

79.3 (7.6–106.1)***

60.8 (22.3–80.7)**

50.3 (0.6–238.9)**

  Free cholesterol (µmol/g liver)

3.94 (2.70–4.54)

3.36 (3.23–3.91)*

3.46 (2.97–4.02)

2.20 (1.13–5.43)**

  Free cholesterol (µmol/liver)

5.08 (3.74–6.44)

6.31 (4.88–7.01)

6.92 (4.71–8.23)**

11.73 (10.23–14.48)***^^^###

  Cholesteryl-esters (µmol/g liver)

0.68 (0.02–0.94)

1.80 (0.57–3.02)**

1.85 (1.16–3.03)**

1.23 (0.10–5.47)*

  Cholesteryl-esters (µmol/liver)

0.83 (0.03–1.65)

3.57 (0.73–4.78)**

3.23 (2.26–5.11)***

7.73 (0.79–11.77)***

  Total cholesterol (µmol/g liver)

4.45 (2.91–5.27)

5.13 (3.98–6.51)

5.27 (4.14–6.68)

3.36 (1.33–10.90)

  Total cholesterol (µmol/liver)

5.87 (4.02–7.93)

10.01 (5.73–10.73)**

9.93 (6.97–13.15)***

20.06 (11.03–24.79)***^^^###

  Protein (mg/liver)

300 (241–401)

381 (290–412)

430 (229–481)**

656 (394–821)***^^^##

Plasma

  Lactate (mmol/L)

3.94 (3.46–5.83)

4.72 (3.53–6.09)

5.62 (4.02–7.17)

5.03 (2.65–6.38)

  Total ketone bodies (mmol/L)

0.072 (0.055–0.112)

0.087 (0.055–0.165)

0.082 (0.059–0.197)

0.123 (0.090–0.224)**^#

  3HB (mmol/L)

0.069 (0.051–0.109)

0.084 (0.052–0.161)

0.079 (0.056–0.192)

0.121 (0.087–0.219)**^#

  ACA (mmol/L)

0.003 (0.002–0.007)

0.004 (0.003–0.007)

0.003 (0.002–0.005)

0.003 (0.000–0.005)

  FFA (µmol/L)

153 (96–259)

166 (129–254)

224 (69–306)

167 (97–409)

  1. *p < 0.05, **p < 0.01, ***p < 0.001 vs shSCR/L-G6pc+/+; ^ vs shChREBP/L-G6pc+/+; # vs shSCR/L-G6pc-/-