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Table 1 Gene set enrichment analysis on RNA-seq data of short-term shSCR- and shChREBP-treated L-G6pc+/+ and L-G6pc−/− mice

From: Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

 

L-G6pc−/− shSCR vs L-G6pc+/+ shSCR

L-G6pc+/+ shChREBP vs L-G6pc+/+ shSCR

L-G6pc−/− shChREBP vs L-G6pc−/− shSCR

Gene set (sizea)

NES

Nominal

p-value

FDR

q-value

NES

Nominal

p-value

FDR

q-value

NES

Nominal

p-value

FDR

q-value

P53 pathway (158)

1.22

0.109

0.286

1.54

0.000

0.034

1.53

0.002

0.026

G2/M checkpoint (153)

1.66

0.000

0.018

0.91

0.704

0.813

1.93

0.000

0.001

Oxidative stress (25)

-0.97

0.474

1.000

1.12

0.295

0.479

1.47

0.045

0.187

Apoptosis (122)

1.11

0.265

0.416

1.54

0.005

0.032

1.66

0.000

0.012

CIN29 (15)

2.15

0.000

0.000

1.97

0.002

0.002

2.07

0.000

0.001

cGAS-STING (39)

-1.10

0.289

0.627

1.03

0.402

0.607

1.90

0.000

0.001

MMC2-senescence (133)

1.33

0.046

0.155

1.79

0.000

0.007

2.19

0.000

0.000

Inflammatory response (114)

1.03

0.408

0.488

1.94

0.000

0.002

1.98

0.000

0.001

Epithelial mesenchymal transition (123)

-1.02

0.408

0.691

1.81

0.000

0.007

2.01

0.000

0.001

  1. asize: refers to the size of the gene set after filtering out those genes that were not in the expression data set