Skip to main content
Fig. 1 | Cancer & Metabolism

Fig. 1

From: Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia

Fig. 1

ChREBP knockdown in hepatic GSD Ia mice causes hepatocyte death, inflammation, DNA damage, and proliferation. (A) Single cell death and inflammatory foci, (B) γH2Ax positivity, (C) p21 (Cdkn1a) expression, and (D) pH3 and Ki67 positivity and mitotic figures in livers after 10 days of shChREBP/L-G6pc−/−. A-D: median ± interquartile range; Kruskal Wallis H-test, post-hoc Conover pairwise comparisons, *p < 0.05, **p < 0.01, ***p < 0.001 vs shSCR/L-G6pc+/+; ^ vs shChREBP/L-G6pc+/+; # vs shSCR/L-G6pc.−/− (n = 7–9)

Back to article page

Cancer & Metabolism

ISSN: 2049-3002