Fig. 5
From: Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer
Response to H2O2 and irradiation after antioxidant inhibition with ML385. Toxicity of H2O2 with or without prior treatment with ML385 on WT and TAM-R (A) MCF7 and (B) MDA-MB-231 cells. Surviving fraction of (C) MCF7 and (D) MDA-MB-231 cells after irradiation with 4 Gy and prior treatment with or without ML385. Data are represented as mean + SD (n = 3). Statistical significance was determined by ANOVA with Sidak post hoc test for the area under the curve (A, B) and surviving fraction (C, D) comparing TAM-R cells to WT cells per condition. *, p < 0.05; ****, p < 0.0001