Fig. 3
From: Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer
ROS production in MCF7 and MDA-MB-231 cells after treatment with different OXPHOS inhibitors and H2O2. Signal intensity of CellROX was measured after several concentrations of tamoxifen (A, B), IACS (C, D), Metformin (E, F) and Tert-butyl hydroperoxide (G, H) and was generally lower in TAM-R cells. Toxicity of H2O2 (I). Data are represented as mean + SD (n = 3). Statistical significance was determined by Student’s t test with Bonferroni correction for the area under the curve comparing TAM-R cells to WT cells per condition. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001