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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells

Fig. 5

Glucose uptake rate by cells pretreated with the serine synthesis inhibitor CBR-5884. Cells were pretreated 2.5 h with 40 μM CBR-5884 or equal volume of DMSO in buffer without (A) or with (B) 1.5 mM glutamine. Average glucose uptake was determined over two 1-h intervals. Data are mean ± SEM of three experiments. * p < 0.05 by paired two-tailed t-test

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Cancer & Metabolism

ISSN: 2049-3002