Skip to main content
Fig. 2 | Cancer & Metabolism

Fig. 2

From: Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells

Fig. 2

Simplified model of folate cycle fluxes. Red arrow reflects measured rate of extracellular (ECF) serine (Ser) accumulation (J22) and blue arrows are inferred fluxes from analysis of 13C serine enrichment (M-M3) from [1,2-13C] glucose. Abbreviations: J19—Ser synthesis from 3-phosphoglycerate (3PG), J20—the contribution of endogenous serine (Serend) from sources other than 3PG to labeling the Ser pool, J21—mitochondrial Ser consumption by the folate cycle that produces glycine (Gly), NADPH, and 10-formyl tetrahydrofolate (fTHF), J22—Ser export to the ECF, J23—Gly consumption by reactions not producing Ser, J24—the contribution of endogenous Gly to labeling the Gly pool, and J25—Ser and tetrahydrofolate production from formate, Gly, and NADPH. Synthesis of purine nucleotides (NTs) recycles fTHF to THF without Ser production from Gly

Back to article page