Skip to main content
Fig. 3 | Cancer & Metabolism

Fig. 3

From: Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

Fig. 3

Possible regulators and functions responding to short-time LAT1 inhibition. A Heatmap showing activation and inactivation of possible regulators commonly detected in at least two cell lines. Activation z-scores of activated or inactivated regulators from phosphoproteomics of KKU-055, KKU-100, and KKU-213 are shown by IPA. B Functional annotation clustering using DAVID for proteins with upregulated and downregulated phosphorylation commonly detected in at least two phosphoproteome results. The table shows the top terms of each cluster. ES, enrichment score; MF, molecular function; BP, biological process; CC, cellular component. C A network of proteins with downregulated phosphorylation commonly detected in at least two phosphoproteomics results. Proteins categorized into two biological processes in DAVID analysis in Fig. 3B, cell cycle process, and RNA splicing, are shown in magenta and green, respectively

Back to article page