Skip to main content
Fig. 2 | Cancer & Metabolism

Fig. 2

From: Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism

Fig. 2

SNHG16 and PTBP1 promote 5-Fu resistance of gastric cancer. a AGS and SGC-7901 cells were transfected with control siRNA or SNHG16 siRNA, and expressions of SNHG16 were examined by qRT-PCR. b, c AGS cells with SNHG16 or PTBP1 silencing were treated with 5-Fu at the indicated concentrations for 48 h. Cell viability was determined by MTT assay and d Annexin V apoptosis assay. e, f SGC-7901 cells with SNHG16 or PTBP1 silencing were treated with 5-Fu at the indicated concentrations for 48 h. Cell viability was determined by MTT assay and g Annexin V apoptosis assay. h AGS parental cells and 5-Fu-resistant cells were treated with 5-Fu for 48 h. Cell viability was determined by MTT assay and clonogenic assay. i Expressions of SNHG16 and PTBP1 were examined in AGS parental and 5-Fu-resistant cells. Data were presented as mean±S.D. *p<0.05; **p<0.01; ***p<0.001

Back to article page

Cancer & Metabolism

ISSN: 2049-3002