Fig. 10

Inhibiting PTBP1 sensitizes gastric tumor to 5-Fu by blocking glycolysis in vivo. a Xenograft mice was subcutaneously injected with AGS 5-Fu-resistant cells. Mice were grouped and treated with control, 5-Fu alone, shPTBP1 alone, or the combination of 5-Fu and PTBP1 silencing. The survival rates of mice were recorded. b Xenograft tumor volumes from the above treated mice were measured and calculated. c Representative mice xenograft tumors from four treatment groups. d mRNA expressions of GLUT1, e HK2, and f LDHA from the above treated xenograft tumors were detected by qRT-PCR. Data were presented as mean±S.D. ***p<0.001