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Fig. 2 | Cancer & Metabolism

Fig. 2

From: Altered acetyl-CoA metabolism presents a new potential immunotherapy target in the obese lung microenvironment

Fig. 2

Obesity impacts acetyl Co-A metabolism in mice. (a) Biocrates metabolomics assay revealed 100 metabolites that were altered in the tumors of obese LLC mice, as compared to non-obese mice (b) which separates normal diet (pink) from diet induced obesity mice (teal) lungs, based on the expression of these metabolites. (c) Boxplots of the top 10 differential metabolites shows significant differences spanning several biochemical classes (p from Limma output). (d) Quantification of metabolites by biochemical classes reveals glycerophospholipids are the most highly dysregulated metabolite classes (e) Mapping of these metabolites, revealed upregulation of pathways consuming Acetyl Co-A (red) to a statistically significant extent (dark red, p < 0.05)

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Cancer & Metabolism

ISSN: 2049-3002