Fig. 1

Obesity impacts transcriptional Acetyl Co-A metabolism in humans, and this is recapitulated in mice similarly. (a) ORIEN patient data, when split into high visceral fat (top tertile) as compared to low visceral fat (lowest tertile) separate in a PCA and (b) reveal several significantly down-regulated (red, left) genes and upregulated (red, right) genes. GSEA of upregulated (c) and downregulated (d) genes reveal several pathways of interest such as cell cycle, epigenetics, immune, and metabolism. Pathways that result in the increased production and consumption of Acetyl Co-A, are transcriptionally upregulated (red) to a statistically significant extent (darker red, p < 0.05) in obese as compared to non-obese tumor tissues in both human ORIEN data (e) and these findings were confirmed in the transcriptional data from the tumors of LLC mice (f)