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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity

Fig. 4

Ketogenic diets normalize the concentration of alpha-amino adipic in melanoma-bearing mice to levels found in non-tumor mice (NTM). AD Correlation plots showing the top 25 metabolites that are significantly associated with the predefined pattern “1–2–1–1” in A A375, B WM47, C WM3311, and D WM3000 melanoma-bearing mice. The pattern “1–2–1–1” corresponds to concentrations of metabolites of the different groups in the following order: “NTM CTRL (1)–melanoma CTRL (2)–melanoma LCT (1)–melanoma LCT-MCT (1)”, while “2” indicates higher metabolite concentrations than “1”. E Absolute μM concentration of alpha-amino adipic acid in plasma of NTM fed with CTRL diet, melanoma-bearing mice fed with CTRL diet and melanoma-bearing mice fed with LCT or LCT-MCT. Individual data points ± SD; n = 7–13; p values were determined by a one-way ANOVA with Šidák’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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