Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish

Monroe, Jerry D.; Fraher, Daniel; Huang, Xiaoqian; Mellett, Natalie A.; Meikle, Peter J.; Sinclair, Andrew J.; Lirette, Seth T.; Maihle, Nita J.; Gong, Zhiyuan; Gibert, Yann

doi:10.1186/s40170-022-00283-y

Cancer & Metabolism

Table 1 Lipid species exhibiting altered levels during HCC

From: Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish

Transgene (dpt)	Lipid species
X-/M+ (1.5)	Dec: Cer22:0; Cer24:0; MHC24:0; SM33:1; SM34:0; SM35:1; SM38:1; SM39:1; SM41:1; SM41:2; SM42:1; PC31:1; PC31:0; PC32:0; PC33:3; PC33:2; PC33:0; PC34:3; PC35:2; PC36:6; PC36:5; PC37:6; PC37:4; PC38:7; PC39:7; PC39:6; PC39:5; PC40:8; PC-P 34:3; PE36:5; PE36:4; PE36:2; PE-O 18:2-22:5; PE-P 18:0-22:5; COH
X-/M+ (1.5)	Inc: dhCer16:0; PC-P 30:0; PE 20:4-0:0; CE16:2; CE18:0; CE18:2; CE18:3; CE20:1; CE22:5; TG14:1-16:0-18:1; TG16:0-16:0-18:2; TG14:0-18:0-18:1
X+/M- (1.5)	Dec: SM41:2; PE-P 18:0-22:5; COH
X+/M- (1.5)	Inc: dhCer16:0; MHC20:0; DHC20:0; GM3 16:0; SM36:1; LPC15:0; LPC17:1; LPC18:0; LPC18:1; LPC20:2; LPC20:3; LPC24:0; PC36:6; PC36:1; PC38:5; PC38:2; PC40:4; PC-O 34:4; PC-O 34:3; PC-O 36:4;PE32:1; PE34:3; PE34:1; PE35:2; PE35:1; PE36:3; PE36:1; PE40:6; PE40:5; PE 20:4-0:0;PI34:1; PI36:1; PI36:4; PI38:5; PI38:6; PI40:5; PI:18:0-0:0; PI:18:1-0:0; PI:20:4-0:0; PG18:1-18:1; DG14:0-14:0; TG14:1-16:0-18:1; TG18:1-14:0-16:0; TG15:0-18:1-16:0; TG17:0-16:0-16:1; TG17:0-18:1-14:0; TG14:0-18:2-18:2; TG14:1-18:0-18:2; TG14:1-18:1-18:1; TG16:1-16:1-18:1; TG16:0-16:0-18:2; TG16:1-16:1-18:0; TG16:0-16:1-18:1; TG14:0-18:0-18:1; TG16:0-16:0-18:1; TG15:0-18:1-18:1; TG17:0-18:1-16:1; TG17:0-18:2-16:0; TG17:0-18:1-16:0; TG16:0-18:2-18:2; TG16:1-18:1-18:2; TG16:1-18:1-18:1; TG16:0-18:1-18:2; TG16:0-18:1-18:1; TG16:0-18:0-18:1; TG17:0-18:1-18:1; TG18:1-18:2-18:2; TG18:0-18:2-18:2; TG18:2-18:2-20:4; TG18:1-18:1-20:4;TG18:1-18:1-22:6
X+/M+ (1.5)	Dec: Cer22:0; MHC24:0; SM33:1; SM35:1; SM38:1; SM41:1; SM41:2; SM42:1; PC33:3; PC33:2; PC34:4; PC34:3; PC35:3; PC36:6; PC36:5; PC36:3; PC36:2; PC37:6; PC37:5; PC37:4; PC38:7; PC38:5; PC38:2; PC39:7; PC39:6; PC39:5; PC40:8; PC-O 36:4; PC-O 40:7; PC-O 40:6; PC-P 34:2; PE36:5; PE36:5; PE36:4; PE36:3; PE36:2; PE38:5; PE38:4; PE38:3; PE 16:0-0:0; PI38:4; PS38:4; COH; DG18:1-18:3
X+/M+ (1.5)	Inc: dhCer16:0; PI34:1; CE16:2; CE18:2; TG14:0-18:0-18:1
X-/M+ (3)	Dec: SM36:1
X-/M+ (3)	Inc: MHC24:0; SM33:1; LPC22:0; PC-O 32:0; PC-O 18:0-0:0; PC-P 34:2; PE38:6; PE38:3; PE40:6; PE40:5; PE 18:1-0:0; PE-O 40:6; PE-P 18:0-22:5; PI:20:4-0:0; CE18:0; CE20:2; CE22:4; CE22:5
X+/M- (3)	Dec: DG14:0-14:0; TG16:1-16:1-16:1; TG16:1-16:1-18:0; TG16:0-16:1-18:1; TG18:2-18:2-20:4
X+/M- (3)	Inc: PC-O 35:4
X+/M+ (3)	Dec: None decreased
X+/M+ (3)	Inc: Cer22:0; Cer24:0; MHC24:0; PC40:4; PC-O 32:0; PC-P 38:5; PE38:6; PE40:6; PE40:5; PE-O 40:6; PE-P 16:0-22:6; PI38:4; CE22:4; CE24:5; TG14:0-16:0-18:2; TG14:1-16:0-18:1; TG17:0-18:1-14:0; TG14:1-18:0-18:2; TG14:0-18:0-18:1; TG16:0-16:0-18:1; TG16:0-18:2-18:2
X-/M+ (4.5)	Dec: PC34:5; PC34:4; PC35:5; PC36:6; PC38:7; PC-P 34:2; CE24:0
X-/M+ (4.5)	Inc: PC38:3; PC-O 35:4; CE16:0; CE16:1; CE17:0; CE17:1; CE18:0; CE18:1; CE18:3; CE20:1; CE20:2; CE20:3; CE20:4; CE22:4; CE22:5; CE24:5; CE24:6
X+/M- (4.5)	Dec: PC-P 34:2
X+/M- (4.5)	Inc: MHC18:0; DHC22:0; SM37:2; SM38:2; LPC16:1; LPC17:1; LPC18:1; LPC18:2; LPC18:3; LPC22:0; PC:18:1-18:3; PC31:1; PC32:2; PC32:1; PC33:2; PC33:1; PC33:0; PC34:3; PC34:2; PC34:1; PC35:1; PC35:0; PC36:3; PC36:2; PC36:1; PC37:4; PC38:3; PC-O 32:2; PC-O 34:3; PC-O 35:4; PC-O 36:3; PC-O 36:2; PC-P 40:6; PE34:3; PE34:2; PE34:1; PE35:1; PE36:3; PE36:2; PE36:1; PE38:6; PE40:7; PE40:5; PE 18:1-0:0; PE 18:2-0:0; PE-O 40:6; PI:18:0-0:0; PI:18:1-0:0; PI:20:4-0:0; PS36:1; PS40:5; CE15:0; CE17:0; CE17:1; CE18:0; CE18:1; CE18:2; CE18:3; CE20:1; CE20:2; CE20:3; CE20:4; CE22:1; CE22:4; CE22:5; CE24:5
X+/M+ (4.5)	Dec: SM32:0; PE36:5; DG14:1-16:0
X+/M+ (4.5)	Inc: Cer16:0; Cer22:0; Cer24:0; MHC18:0; GM3 22:0; GM3 24:1; LPC14:0; LPC16:1; LPC18:0; LPC20:0; LPC20:1; LPC24:0; PC29:0; PC32:0; PC-O 32:0; PC-O 35:4; PC-O 36:5; PE34:3; PE34:1; PE36:3; PE36:2; PE 16:0-0:0; PE 18:1-0:0; PE 18:2-0:0; PI:18:1-0:0; CE16:0
X-/M+ (6)	Dec: None decreased
X-/M+ (6)	Inc: Cer16:0; Cer18:0; Cer20:0; Cer22:0; Cer24:0; Cer24:1; MHC18:0; SM36:3; SM38:1; SM39:1; SM41:2; PC:18:1-18:3; PC31:0; PC32:1; PC33:2; PC33:1; PC33:0; PC34:5; PC34:1; PC35:4; PC35:3; PC35:2; PC35:1; PC35:0; PC36:3; PC36:2; PC36:1; PC36:0; PC37:5; PC37:4; PC38:4; PC38:2; PC39:7; PC39:6; PC39:5; PC40:8; PC40:5; PC-O 20:0-0:0; PE38:6; PE40:7; PE40:6; PE40:5; PE-O 40:6; PI:18:0-0:0; PI:18:1-0:0; CE16:2; CE17:0
X+/M- (6)	Dec: None decreased
X+/M- (6)	Inc: Cer16:0; Cer20:0; Cer22:0; Cer24:0; Cer24:1; MHC16:0; MHC20:0; MHC22:0; MHC24:0; DHC16:0; DHC22:0; DHC24:0; GM3 24:1; SM34:1; SM35:2; SM37:2; SM38:1; SM38:2; SM39:1; SM41:1; SM41:1; SM41:2; SM42:1; LPC17:0; LPC18:0; PC:18:1-18:3; PC30:0; PC31:0; PC32:3; PC32:2; PC32:1; PC32:0; PC33:2; PC33:1; PC33:0; PC34:1; PC34:0; PC35:4; PC35:2; PC35:1; PC35:0; PC36:3; PC36:2; PC36:1; PC37:4; PC38:5; PC38:2; PC40:5; PC40:4; PC-O 32:2; PC-O 32:1; PC-O 32:0; PC-O 34:2; PC-O 34:1; PC-O 36:5; PC-O 36:3; PC-O 40:7; PC-O 18:1-0:0; PC-O 20:0-0:0; PC-P 36:2; PE32:1; PE34:2; PE34:1; PE35:2; PE36:2; PE36:1; PE40:7; PE40:6; PE40:5; PE 16:0-0:0; PE 18:0-0:0; PE 18:1-0:0; PE 18:2-0:0; PE 22:6-0:0; PE-O 40:6; PI34:1; PI36:1; PI36:2; PI40:6; PI:18:1-0:0; PS36:1; PS38:3; PS38:4; PS40:5; PS40:6; CE15:0; CE16:0; CE16:2; CE17:0; CE17:1; CE18:0; CE18:1; CE20:1; CE22:1; CE24:1; COH
X+/M+ (6)	Dec: PC37:6; PC37:5
X+/M+ (6)	Inc: dhCer16:0; dhCer18:0; Cer16:0; Cer18:0; Cer20:0; Cer22:0; Cer24:0; Cer24:1; MHC16:0; MHC22:0; DHC16:0; DHC22:0; DHC24:0; DHC24:1; GM3 16:0; GM3 22:0; GM3 24:1; SM36:1; SM37:2; SM38:2; SM39:1; LPC14:0; LPC20:1; LPC22:5; PC:16:0-20:4; PC31:1; PC32:1; PC32:0; PC33:0; PC34:3; PC34:1; PC34:0; PC35:4; PC35:2; PC35:1; PC35:0; PC36:3; PC36:2; PC36:1; PC37:4; PC38:5; PC38:3; PC38:2; PC40:4; PC-O 32:1; PC-O 32:0; PC-O 34:4; PC-O 34:3; PC-O 34:2; PC-O 34:1; PC-O 36:5; PC-O 36:4; PC-O 36:1; PC-O 38:5; PC-O 38:4; PC-O 20:0-0:0; PC-O 22:1-0:0; PC-P 32:0; PC-P 34:3; PC-P 34:1; PC-P 36:2; PC-P 38:5; PE32:1; PE34:3; PE34:2; PE34:1; PE35:2; PE35:1; PE36:3; PE36:2; PE36:1; PE38:6; PE38:4; PE38:3; PE40:7; PE40:6; PE40:5; PE40:4; PE 16:0-0:0; PE 18:0-0:0; PE 18:1-0:0; PE 18:2-0:0; PE 20:4-0:0; PE-O 40:6; PE-P 16:0-22:6; PE-P 18:0-22:6; PI34:1; PI36:3; PI36:4; PI38:5; PI38:6; PS38:3; PS40:5; PS40:6; PG18:1-18:1; CE16:2; CE18:1; CE18:3; CE20:1; CE20:2; CE20:3; CE20:4; CE20:5; CE22:1; CE22:4; CE22:5; CE24:1; CE24:5; COH; TG16:1-16:1-18:1
X-/M+ (7.5)	Dec: SM34:0; TG14:1-16:0-18:1; TG14:1-16:1-18:0; TG15:0-18:1-16:0; TG15:0-18:1-16:0
X-/M+ (7.5)	Inc: dhCer16:0; Cer16:0; Cer20:0; Cer22:0; Cer24:0; Cer24:1; MHC20:0; MHC22:0; SM41:2; LPC14:0; LPC15:0; LPC16:1; LPC17:0; LPC17:1; LPC18:1; LPC18:2; LPC18:3; LPC20:1; LPC20:2; LPC20:3; LPC20:4; PC:18:1-18:3; PC:16:0-22:6; PC29:0; PC30:0; PC31:1; PC31:0; PC32:1; PC32:0; PC33:2; PC33:1; PC33:0; PC34:1; PC35:4; PC35:3; PC35:1; PC36:3; PC36:2; PC36:1; PC37:4; PC38:2; PC39:7; PC39:6; PC39:5; PC40:8; PC40:7; PC40:6; PC40:5; PC40:4; PC-O 34:3; PC-O 34:2; PC-O 34:1; PC-O 36:5; PC-O 40:7; PC-O 20:1-0:0; PC-P 34:1; PC-P 38:6; PC-P 38:5; PC-P 40:6; PE34:3; PE34:2; PE34:1; PE35:2; PE35:1; PE36:3; PE36:2; PE38:6; PE40:7; PE40:6; PE40:5; PE 16:0-0:0; PE 18:1-0:0; PE 18:2-0:0; PE-O 40:6; PE-P 16:0-22:6; PI34:1; PI36:3; PI36:4; PI38:4; PI38:5; PI38:6; PS38:4; PS40:5; PS40:6; COH; DG14:0-18:1; DG16:1-18:1; DG16:0-18:1; DG18:0-16:1; DG18:1-18:2; DG18:1-18:1
X+/M- (7.5)	Dec: None decreased
X+/M- (7.5)	Inc: Cer16:0; Cer20:0; Cer22:0; Cer24:0; Cer24:1; MHC16:0; MHC22:0; MHC24:0; DHC16:0; DHC22:0; DHC24:0; DHC24:1; SM36:1; SM38:1; SM38:2; SM41:1; SM41:2; SM42:1; LPC14:0; LPC15:0; LPC16:0; LPC16:1; LPC17:0; LPC17:1; LPC18:0; LPC18:1; LPC18:2; LPC18:3; LPC20:0; LPC20:1; LPC20:2; LPC20:3; LPC20:4; LPC20:5; LPC22:5; LPC22:6; PC30:0; PC31:1; PC31:0; PC32:1; PC32:0; PC33:3; PC33:2; PC33:1; PC33:0; PC34:4; PC34:3; PC34:2; PC34:1; PC34:0; PC35:4; PC35:3; PC35:1; PC36:6; PC36:3; PC36:2; PC36:1; PC37:4; PC38:7; PC38:3; PC38:2; PC39:7; PC40:8; PC40:6; PC40:4; PC-O 32:1; PC-O 32:0; PC-O 34:3; PC-O 34:2; PC-O 34:1; PC-O 40:7; PC-O 16:0-0:0; PC-O 18:0-0:0; PC-O 18:1-0:0; PC-O 20:1-0:0; PC-O 22:1-0:0; PC-P 30:0; PC-P 34:3; PC-P 36:2; PE32:1; PE34:3; PE34:2; PE34:1; PE35:2; PE35:1; PE36:3; PE36:2; PE36:1; PE38:6; PE40:7; PE40:6; PE40:5; PE 18:0-0:0; PE 18:1-0:0; PE 20:4-0:0; PE 22:6-0:0; PE-O 40:6; PE-O 18:0-22:5; PI34:1; PI36:2; PI36:3; PI36:4; PI38:5; PI38:6; PI40:5; PS40:5; PS40:6; CE14:0; CE16:2; COH; DG14:0-18:1; DG16:0-18:2; DG16:1-18:1; DG16:0-18:1; DG18:0-16:1; DG18:2-18:2; DG18:1-18:2; DG18:1-18:1; DG18:1-20:4; DG18:1-20:3
X+/M+ (7.5)	Dec: TG18:0-18:2-18:2; TG18:1-18:1-20:4
X+/M+ (7.5)	Inc: Cer20:0; Cer22:0; MHC18:0; MHC22:0; DHC22:0; GM3 16:0; GM3 22:0; GM3 24:1; SM41:2; LPC16:0; LPC16:1; LPC17:1; LPC18:0; LPC18:1; LPC18:2; LPC18:3; LPC20:0; LPC20:1; LPC20:2; LPC20:3; LPC20:4; LPC20:5; LPC22:5; LPC22:6; PC:18:1-18:3; PC29:0; PC33:0; PC35:4; PC35:2; PC35:0; PC36:3; PC36:0; PC-O 32:0; PC-O 34:3; PC-O 16:0-0:0; PC-O 18:0-0:0; PC-O 18:1-0:0; PC-O 20:0-0:0; PC-O 22:1-0:0; PE32:1; PE34:2; PE36:3; PE36:2; PE 16:0-0:0; PE 18:0-0:0; PE 18:1-0:0; PE 18:2-0:0; PE 20:4-0:0; PE 22:6-0:0; PI34:1; PI36:1; PI36:3; PI:18:0-0:0; PG18:1-18:1; CE17:0; CE18:1; CE22:0; CE22:4

Comprehensive listing of all lipid species with altered levels during HCC. Lipid species with the most decreased and increased levels are shown in bold text with underlining. Key: x−m−, non-transgenic control; x+m−, xmrk oncogene expression; x−m+, Myc oncogene expression; x+m+, xmrk and Myc oncogene expression; Inc increase, Dec decrease

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ISSN: 2049-3002

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