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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Fig. 4

Altered pancreatic adipocyte area in mice with reduced hyperinsulinemia. AB Representative high-magnification image of apparent adipocyte replacement of pancreas area in male (A) and female (B) PK-Ins1-/-;Ins2+/+ (left) and PK-Ins1-/-;Ins2+/- (right) mice stained with H&E. Black arrows point to residual ducts. Arrowheads point to remaining islets, acinar cells, and blood vessel. Scale bars: 0.5 mm. CD Quantification of percent of total pancreatic area occupied by adipocytes in male and female mice of each genotype (n= 11–22). Correlations of adipocyte area with fasting insulin levels (EF), fasting glucose levels (GH), or body weight (IJ) for male (E, G, I) and female (F, H, J) PK-Ins1-/-;Ins2+/+ (dark colors) and PK-Ins1-/-;Ins2+/- (light colors) mice (n = 11–22). Values are shown as mean ± SEM

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