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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Fig. 3

Altered ADM in mice with reduced hyperinsulinemia. AB Representative high-magnification ADM (arrowheads) images of male (A) and female (B) PK-Ins1-/-;Ins2+/+ (left) and PK-Ins1-/-;Ins2+/- (right) mouse pancreas sections stained with H&E. Scale bars: 0.05 mm. CD Quantification of percent of total pancreatic area occupied by ADM in male and female mice of each genotype (n = 10–22). Correlations of composite ADM area with PanIN area in non-tumor bearing (E–F), fasting insulin levels (GH), fasting glucose (IJ), or body weight (KL) in male (E, G, I, K) and female (F, H, J, L) PK-Ins1-/-;Ins2+/+ and PK-Ins1-/-;Ins2+/- mice (n = 10–16). Values are shown as mean ± SEM

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