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Fig. 2 | Cancer & Metabolism

Fig. 2

From: Combined inhibition of HMGCoA reductase and mitochondrial complex I induces tumor regression of BRAF inhibitor-resistant melanomas

Fig. 2

Cell growth inhibition by treatment combinations that showed synergistic combo scores. AE A375R1 cells were seeded in 96-well plates (103 cells/well) and treated with individual probes and their combinations with IACS at 1:1 concentration shown on the x-axes. Cell growth inhibition was determined after 72 h using Cell Titer Blue reagent. F–J Same experiment as above, conducted on UCSD354L cells. Data is normalized to vehicle-treated cells and is average of triplicates, with error bars representing standard deviation (SD), and colored asterisks representing significant differences (*< 0.033, **< 0.002, and ***< 0.001) in effects for combination treatment versus individual probes (red) or IACS (black)

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