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Fig. 7 | Cancer & Metabolism

Fig. 7

From: Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX

Fig. 7

Graphical representation of extracellular pH analyzed in C33-a CA IX (A) cells after treatment with CA9hu-1 (HC4LC4) or CA9hu-2 (HC4LC5) for 48 h in hypoxia, n = 6, pH values were normalized to cell numbers. B, C The ability of humanized antibodies to inhibit invasion of cancer cells in comparison with no Ab treatment. The invasion ability of C33-a cells expressing CA IX was significantly reduced after the treatment with both humanized antibody variants. Data in the graph represent the mean ± standard deviation values. Statistical significance of differences was assessed using Student’s t-test (*P < 0.05, **P < 0.01, ***P < 0.001), n = 6

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Cancer & Metabolism

ISSN: 2049-3002