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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin

Fig. 4

Validation of HK1-induced effects in the mouse model. a Tumor volume resulting from the subcutaneous xenotransplantation of TOV-112D control cells, HK1 and HK2 as evaluated at post-transplantation days 12, 15, and 18. b Endpoint outcomes of the experiment presented in Fig. 4a as evaluated at post-transplation day 30. c Endpoint outcomes of the subcutaneous xenotransplantation of the TOV-112D control cells, HK1 cells, and HK1 revertants into mice that were fed with the glucose-deficient diet as evaluated at post-transplantation day 30. d Sample photographs of tumors in mice that were fed with the glucose-deficient diet after dissection, including the only tumor that developed in the cohort transplanted with HK1 TOV-112D

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