Fig. 6

The clinical significance of miR-377-3p and CPT1C in HCC patients. A Representative miRNA in situ hybridization of miR-377-3p or immunohistochemical staining of CPT1C in 90 paired HCC tumor and adjacent normal tissues. Scale bar 50 μm. H scores of miR-377-3p or CPT1C expression between tumor and normal tissues were compared by Mann-Whitney U test. B Kaplan-Meier survival curves for overall survival of 72 HCC patients according to the relative expression of miR-377-3p and CPT1C. C Representative MISH of miR-377-3p or IHC staining of CPT1C or BODIPY 493/503 staining of lipid droplets in 90 HCC tissues. Correlation was determined between miR-377-3p and CPT1C expression (left panel), between CPT1C expression and lipid droplets (middle panel) and between miR-377-3p expression and lipid droplets (right panel) in 90 HCC patients. Scale bar 50 μm. The p value was generated using Spearman’s rank correlation test