Fig. 4

Associations between mTCs and drug sensitivity for the selected examples. A Spearman correlations between drug IC₅₀ values and the activity of GDSC mTC 3. B Scatter plot showing the association between the (log-transformed) IC₅₀ value of nutlin-3a and the activity of GDSC mTC 3 in samples. The transparency of the dots is the same for all data points. Darker dot colors therefore mean that multiple data points are overlapping. C Box plot of the activity of GDSC mTC 3 across cell lines, colored for their TP53 mutation status. D Pair-wise correlations between GDSC mTC 3 and mTCs from the GEO, TCGA, and CCLE datasets. Every dot corresponds to an mTC with a correlation to GDSC mTC 3 of ≥ 0.5. Dot sizes correspond to the P-value of the Spearman correlation coefficient; the y-axis gives the percentage of the overlapping top genes between the two mTCs involved in the correlation. E Spearman correlations between the drug IC₅₀ values and the activity of CCLE mTC 4. F Box plot of the activity of CCLE mTC 4 across cell lines, colored for their TP53 mutation status. G–J Spearman correlations between the drug IC₅₀ values and the activity of GDSC mTC 18, CCLE mTC 28, GDSC mTC 108, and CCLE mTC 97, respectively