Skip to main content
Fig. 1 | Cancer & Metabolism

Fig. 1

From: Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer

Fig. 1

MYC directly upregulates glycolysis expression. A–C Bimodal MYC gene stratification of SCLC samples in the George et al., Gay et al., and Sato et al. datasets [11, 37, 38]. D Venn diagram showing the 266 upregulated gene commonalities among the three datasets. E Of the 266 upregulated genes, 36.9% can be linked to a metabolic process through Panther Gene Ontology Biological Pathway Analysis. F Similarly, several of the top GO terms generated by David Functional Enrichment Analysis are involved in central carbon and glucose metabolism. G and H Glycolysis genes HK2, PFKFB3, and LDHA exhibit increased expression in the MYCHigh subset of patient tumors [11] and cell lines [37], respectively. I HK2, PFKFB3, and LDHA protein expression by RPPA is also increased in MYCHigh cell lines. J ChIP-seq analysis of MYC (red) and H3K27Ac (blue) genomic binding at indicated gene loci from N = 4 RPM tumor samples. Arrows indicate directionality of the gene

Back to article page