Fig. 1
From: Brief report: The uricase mutation in humans increases our risk for cancer growth
Promotion of tumor growth and metastasis in mice lacking active uricase. Pharmacologic inhibition of uricase augmented the growth and distant metastasis of E0771 syngeneic breast cancer in vivo. Macroscopic tumor volume was measured (A) and lung histology were analyzed for lung metastasis (B) (tumor volume and lung metastasis shown as histogram, n=6 mice per group). Genetic inhibition of uricase using homozygous knockout mice (UOX KO) compared with control as well as mice overexpressing uricase (UOX Tg) were used for experiments. Tumor volume was measured during a 28-day growth period (C) (tumor volume shown as histogram, from n=3 independent experiments). At the end of experiment, mice were sacrificed and lung histology were analyzed for lung metastasis (D) (tumor metastasis shown as histogram, n=6 mice per group). Blood samples were collected at the end of experiment. Serum samples from control non-tumor bearing mice were analyzed for urate level (E) (serum uric acid level shown as histogram, n=6 mice per group). The threshold for statistically significance is indicated as *p ≤0.05, *** p ≤0.001