Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma

Table 1 Pathway analysis of differential metabolites from global metabolomics

Pathways	Hits	Raw p	Holm adjust	FDR	Impact
Pyruvate metabolism	1	0.047	0.901	0.083	0.207
Alanine, aspartate and glutamate metabolism	4	0.029	0.668	0.083	0.197
Citrate cycle (TCA cycle)	3	0.016	0.389	0.083	0.169
Arginine and proline metabolism	5	0.043	0.901	0.083	0.156
Glycolysis/gluconeogenesis	1	0.047	0.901	0.083	0.100
Glycine, serine, and threonine metabolism	4	0.044	0.901	0.083	0.093
Glyoxylate and dicarboxylate metabolism	4	0.022	0.524	0.083	0.032
Propanoate metabolism	1	0.032	0.711	0.083	0
Cysteine and methionine metabolism	1	0.047	0.901	0.083	0
Tyrosine metabolism	1	0.047	0.901	0.083	0
Butanoate metabolism	2	0.050	0.901	0.083	0

Hits matched metabolites in the pathway, raw p original p value calculated from enrichment analysis, Holm adjust adjust p value from Bonferroni method, FDR false discovery rate, Impact pathway impact calculated from topology analysis

ISSN: 2049-3002