The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study

Table 4 Linear associations for MS components with U-shaped relation to head and neck cancer risk

MS components	Model 1		Model 2		Model 3
MS components	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Waist circumference (female)
<93.16 cm	0.94[0.80, 1.11]	0.469	0.94[0.80, 1.11]	0.471	0.92[0.78, 1.08]	0.311
≥93.16 cm	1.42[1.11, 1.80]	0.005	1.41[1.11, 1.80]	0.005	1.47[1.15, 1.89]	0.003
HDL-C (male)
<1.26 mmol/L	0.85[0.75, 0.97]	0.013	0.85[0.75, 0.97]	0.013	0.88[0.77, 1.00]	0.050
≥1.26 mmol/L	1.21[1.08, 1.36]	0.001	1.22[1.09, 1.36]	0.001	1.19[1.06, 1.34]	0.003
HDL-C (female)
<1.45 mmol/L	0.90[0.70, 1.14]	0.384	0.90[0.70, 1.14]	0.381	0.91[0.71, 1.17]	0.462
≥1.45 mmol/L	1.05[0.88, 1.27]	0.576	1.05[0.88, 1.27]	0.567	1.10[0.92, 1.33]	0.301
Blood glucose
<4.70 mmol/L	0.93[0.80, 1.08]	0.330	0.97[0.84, 1.12]	0.674	0.96[0.83, 1.11]	0.577
≥4.70 mmol/L	1.14[1.06, 1.22]	0.001	1.10[1.02, 1.19]	0.010	1.10[1.01, 1.19]	0.022
Diastolic blood pressure
<83 mmHg	1.13[1.02, 1.25]	0.022	1.07[0.96, 1.18]	0.221	1.09[0.98, 1.21]	0.121
≥83 mmHg	1.03[0.94, 1.14]	0.538	0.99[0.90, 1.10]	0.917	0.99[0.90, 1.09]	0.886

Model 1: unadjusted
Model 2: age and gender-stratified model
Model 3: additionally adjusted for education, ethnic, Index of multiple deprivation, alcohol consumption, smoking status, physical activity, fruit and vegetable intake, NASIDS use and CRP

ISSN: 2049-3002