The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study

Table 2 Risk of head and neck cancer according to MS and its components

	No of cases/person-years	Model 1		Model 2		Model 3
	No of cases/person-years	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
Presence of MS
No	495/ 2201184	Reference		Reference		Reference
Yes	311/ 910374	1.27[1.10, 1.47]	0.001	1.18[1.02, 1.36]	0.023	1.05[0.90, 1.22]	0.560
No. of MS components
0–2	483/2167132	Reference		Reference		Reference
3	191/582520	1.25[1.06, 1.48]	0.009	1.14[0.96, 1.35]	0.126	1.04[0.88, 1.24]	0.645
4	95/283291	1.26[1.01, 1.57]	0.043	1.16[0.93, 1.45]	0.187	1.00[0.80, 1.26]	0.978
5	37/78614	1.70[1.22, 2.38]	0.002	1.58[1.13, 2.21]	0.008	1.30[0.92, 1.84]	0.132
Center obesity
No	500/2065978	Reference		Reference		Reference
Yes	304/1036668	1.10[0.95, 1.26]	0.211	1.19[1.04, 1.38]	0.015	1.04[0.90, 1.21]	0.592
Dyslipidemia for TG
No	141/845849	Reference		Reference		Reference
Yes	665/2262915	1.31[1.13, 1.51]	<0.001	1.06[0.91, 1.23]	0.461	0.95[0.81, 1.10]	0.472
Dyslipidemia for HDL-C
No	301/1501095	Reference		Reference		Reference
Yes	464/1438442	1.16[0.98, 1.39]	0.091	1.17[0.98, 1.39]	0.087	1.01[0.84, 1.22]	0.877
Hypertention
No	528/2095502	Reference		Reference		Reference
Yes	160/568287	1.23[1.02, 1.48]	0.027	1.02[0.84, 1.22]	0.874	1.00[0.82, 1.20]	0.973
Hyperglycemia
No	529/2226708	Reference		Reference		Reference
Yes	174/459089	1.35[1.14, 1.61]	0.001	1.26[1.06, 1.5]	0.009	1.22[1.02, 1.45]	0.028

Model 1: unadjusted
Model 2: age and gender-stratified model
Model 3: additionally adjusted for education, ethnic, index of multiple deprivation, alcohol consumption, smoking status, physical activity, fruit and vegetable intake, NASIDS use and CRP

ISSN: 2049-3002