Fig. 7
From: Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
Schematic representation of glutaminolysis genes differentially expressed in GBM. GBM cases presented hyperexpression of GLSiso2 and hypoexpression of other genes of the glutaminolysis pathway (GLSiso1, GLS2, GLUD1, GPT2), (downregulation of GLUD1 and GPT2 was confirmed at protein level) leading to an accumulation of Glu and activation of GSH synthesis and consequently inducing tumor cell proliferation and survival. On the other hand, AGII and AGIII IDH1mut display hyperexpression of GLSiso2, GLUD1, and GPT2 (upregulation of GLUD1 was confirmed at protein level) leading to activation of glutaminolysis pathway and fueling the TCA cell cycle. Additionally, in IDH1mut cases, a decrease in Glu availability sensitizes the tumor cells to oxidative stress leading to slow tumor growth. The downregulated expression is represented by blue thermometers, upregulated by red thermometers, and the non-significant differential expression in gray. Red arrows represent the activation of the pathway and blue arrows represent the inactivation of the pathway