Fig. 5
From: Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
AGII, AGIII TCGA dataset: glutaminolysis- and GSH synthesis-related gene expressions according to IDH1 mutation. a Heatmap representing the expression levels of genes presenting statistical significance in AGII and AGIII with wild type (wt) and mutated IDH1 (mut). Upregulated values are represented in red and downregulated in blue. The RPKM values were normalized by z-score. b The differential expression levels of GLUD1 and GPT2 in each stratified group. (Mann-Whitney test: *p < 0.05, **p < 0.01; ***p < 0.0005, ****p < 0.0001). Horizontal bars show the median expression in each group for the up panels, while the bottom panel boxes represent the first (top) and third (bottom) quartiles, and the median is represented by the middle line in the boxes. The results are presented in the log2 scale of RPKM values. c Spearman correlation matrix among the gene expression levels of each group. The color bar on the right indicates the level of correlation ranging from dark orange (negative correlation) to blue (positive correlation). The color intensiveness and the circle sizes are proportional to r values. Only the correlations with p < 0.05 are plotted