Fig. 1
From: Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
Expression analysis of genes coding for glutaminolysis in astrocytomas of different malignant grades. a GLSiso1, GLSiso2, GLS, GLS2, GLUD1, GOT1, GOT2, and GPT2 expression levels in non-neoplastic brain tissue (NN) compared to pilocytic astrocytoma (AGI), low-grade astrocytoma (AGII), anaplastic astrocytoma (AGIII), and glioblastoma (GBM). The expression levels differ significantly among the groups for all genes analyzed (**p = 0.002, ***p < 0.0001, Kruskal-Wallis test) and between NN and each tumor group (post hoc Dunn test, where ****p < 0.0001, ***p < 0.0005, **p < 0.005, and *p < 0.05. The significant comparison between the groups is represented by different symbols: NN (*), AGI (α), AGII ($), and AGIII (#). Horizontal bars show the median of each group. The results are presented on a log10 scale. b Correlation matrix showing the gene expression correlations with each other in all groups analyzed. Positive correlations are shown in blue and negative correlations in dark orange. The color intensiveness and the size of the circle are proportional to the value of r by the Spearman test. Only the correlations with p < 0.05 are plotted