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Fig. 2 | Cancer & Metabolism

Fig. 2

From: TNF-α differentially modulates subunit levels of respiratory electron transport complexes of ER/PR +ve/−ve breast cancer cells to regulate mitochondrial complex activity and tumorigenic potential

Fig. 2

Differentially expressed proteins identified by proteomics correlates with TNF-α regulated mitochondrial function in breast cancer cells. The raw protein abundance count of mitochondrial protein subunits from untreated and TNF-α treated triplicates from both cells were exported and plotted as a ratio of log-fold change. The encircled proteins show the log-fold change of unique proteins in both cells. a The protein subunits of the CI complex are clustered and color-coded into respective modules according to their function. NC represents a non-characterized component of CI complex. bd The log-fold change of unique proteins for CII, CIII, and CIV in both cell lines respectively (e) western blot analysis of complex III proteins UQCRC2 and LYRM7 in MCF-7 and MDA-MB-231 in the presence of TNF-α

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