Fig. 3
From: Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Central role of reactive oxygen species (ROS) in AML biology and treatment. A representation of the wide variety of factors that produce and limit the production of ROS in AML, along with the outcomes of excess ROS production in these cells. ETC: electron transport chain; FOXO: forkhead box protein O; HDACi: histone deacetylases inhibitors; HIF-1α: hypoxia-inducible factor 1α; JNK: c-Jun N-terminal kinase; Nrf2: nuclear factor erythroid 2-related factor 2; NOX: NADH-oxidases; OxPhos: oxidative phosphorylation; PTM: post-translational modifications