Fig. 2
From: Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Mitochondrial electron transport chain (ETC) as a therapeutic target in AML. A schematic representation of the ETC, showing the five complexes and potential therapeutic compounds that target each. Also shown is ROS, since the ETC is a major producer of the ROS in the cell by way of electron leak through complexes I and III. ATO: arsenic trioxide; α-TOS: (+)alpha-tocopheryl succinate; ANT: adenine nucleotide translocator; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; DHODH: dihydroorotate dehydrogenase; ROS: reactive oxygen species; SR4,9: dichlorophenyl urea compounds; UCP2: uncoupling protein 2; I–V: complexes of mitochondrial electron transport chain