Fig. 1
From: Mitochondrial metabolism as a target for acute myeloid leukemia treatment
Druggable mitochondrial targets in AML cell and selected pharmacological agents. A depiction of mitochondria, showing important biochemical targets (e.g., the citric acid cycle, mtDNA, mitophagy, etc.) and the drugs that are known to target each. The electron transport chain appears in Fig. 2. α-TOS: (+)alpha-tocopheryl succinate; ANT: adenine nucleotide translocator; ATO: arsenic trioxide; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; CPT1: carnitine O-palmitoyltransferase 1; DAP: 2,2-dichloroacetophenone; DCA: dichloroacetate; ddC: 2′3′-dideoxycytidine; DHODH: dihydroorotate dehydrogenase; FAO: fatty acid oxidation; glucoso-6-P: glucose-6-phosphate; IDH2mut: mutant isocitrate dehydrogenase 2; Mcl1: myeloid cell leukemia 1; miR: miRNA; mtDNA: mitochondrial DNA; PDC: pyruvate dehydrogenase complex; PDK: pyruvate dehydrogenase kinase; ROS: reactive oxygen species; SR4,9: dichlorophenyl urea compounds; CAC: citric acid cycle; UCP2: uncoupling protein 2; 2-DG: 2-deoxy-d-glucose; 3-BP: 3-bromopyruvate; 3-BrOP: 3-bromo-2-oxopropionate-1-propyl ester; I–V: Complexes of mitochondrial electron transport chain