Fig. 7
From: Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1
SMAR1 inhibits in vivo tumor formation. a Tumors generated in NOD/SCID mice upon injection of adeno-SMAR1-transduced MDA-MB-231 cells compared with control (n = 4). b, c Graphs representing the Tumor weight and Tumor volume. d, e Expression of PKM isoforms was checked in xenograft samples by western blot and immunohistochemistry. Error bars show mean values ± SD. Differences were considered statistically significant with *p < 0.05, **p < 0.01, and ***p < 0.001; ns non-significant difference (p > 0.05)