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Table 5 Expression of target genes in patients with clear-cell renal-cell carcinoma characterized by high/low ISUP nuclear grade

From: Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial

  Low-grade High-grade Pa Pb
mRNA expression (× 100) (N = 116) (N = 84)
  Frozen tissue    
FOXC2 14.360 ± 29.842 9.820 ± 19.779 0.226 0.855
CLIP4 10.332 ± 15.012 17.307 ± 33.837 0.080 0.911
PBRM1 7.592 ± 8.283 8.543 ± 12.242 0.538 0.391
SETD2 2.615 ± 2.606 0.619 ± 0.633 < 0.001 0.095
BAP1 3.074 ± 12.171 19.778 ± 64.299 0.021 0.831
KDM5C 1.911 ± 4.806 1.763 ± 2.970 0.803 0.553
AQP1 2.337 ± 1.052 0.631 ± 0.903 < 0.001 0.117
DDX11 1.177 ± 2.103 12.763 ± 9.870 < 0.001 < 0.001
BAIAP2L1 3.155 ± 4.468 2.084 ± 2.931 0.042 0.448
TMEM38B 6.567 ± 12.125 4.838 ± 7.751 0.221 0.511
  Plasma    
FOXC2 16.649 ± 8.717 16.226 ± 11.721 0.770 0.490
CLIP4 16.241 ± 20.357 18.619 ± 24.948 0.460 0.333
PBRM1 5.672 ± 38.886 2.065 ± 1.880 0.397 0.538
SETD2 2.736 ± 1.488 0.610 ± 0.771 < 0.001 0.269
BAP1 26.289 ± 146.051 132.993 ± 435.106 0.033 0.520
KDM5C 6.804 ± 8.069 14.961 ± 21.136 0.001 0.964
AQP1 8.376 ± 16.698 12.376 ± 19.408 0.129 0.965
DDX11 3.545 ± 7.810 4.778 ± 8.911 0.311 0.953
BAIAP2L1 5.098 ± 12.002 10.425 ± 16.291 0.012 0.827
TMEM38B 21.343 ± 30.192 17.099 ± 24.749 0.277 0.950
  1. Data are shown as the means ± standard deviations
  2. aP values determined using Student’s t test for univariate analysis
  3. bP values determined using logistic regression for multivariate analysis