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Table 5 Expression of target genes in patients with clear-cell renal-cell carcinoma characterized by high/low ISUP nuclear grade

From: Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial

 

Low-grade

High-grade

Pa

Pb

mRNA expression (× 100)

(N = 116)

(N = 84)

 

Frozen tissue

   

FOXC2

14.360 ± 29.842

9.820 ± 19.779

0.226

0.855

CLIP4

10.332 ± 15.012

17.307 ± 33.837

0.080

0.911

PBRM1

7.592 ± 8.283

8.543 ± 12.242

0.538

0.391

SETD2

2.615 ± 2.606

0.619 ± 0.633

< 0.001

0.095

BAP1

3.074 ± 12.171

19.778 ± 64.299

0.021

0.831

KDM5C

1.911 ± 4.806

1.763 ± 2.970

0.803

0.553

AQP1

2.337 ± 1.052

0.631 ± 0.903

< 0.001

0.117

DDX11

1.177 ± 2.103

12.763 ± 9.870

< 0.001

< 0.001

BAIAP2L1

3.155 ± 4.468

2.084 ± 2.931

0.042

0.448

TMEM38B

6.567 ± 12.125

4.838 ± 7.751

0.221

0.511

 

Plasma

   

FOXC2

16.649 ± 8.717

16.226 ± 11.721

0.770

0.490

CLIP4

16.241 ± 20.357

18.619 ± 24.948

0.460

0.333

PBRM1

5.672 ± 38.886

2.065 ± 1.880

0.397

0.538

SETD2

2.736 ± 1.488

0.610 ± 0.771

< 0.001

0.269

BAP1

26.289 ± 146.051

132.993 ± 435.106

0.033

0.520

KDM5C

6.804 ± 8.069

14.961 ± 21.136

0.001

0.964

AQP1

8.376 ± 16.698

12.376 ± 19.408

0.129

0.965

DDX11

3.545 ± 7.810

4.778 ± 8.911

0.311

0.953

BAIAP2L1

5.098 ± 12.002

10.425 ± 16.291

0.012

0.827

TMEM38B

21.343 ± 30.192

17.099 ± 24.749

0.277

0.950

  1. Data are shown as the means ± standard deviations
  2. aP values determined using Student’s t test for univariate analysis
  3. bP values determined using logistic regression for multivariate analysis