Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial

Table 4 Predictors of high visceral adiposity in clinical T1a clear-cell renal-cell carcinoma

	Univariate		Multivariate
	OR (95% CI)	P^a	OR (95% CI)	P^b
Clinical parameters
Gender (reference male)	0.055 (0.019–0.162)	< 0.001	0.000 (0.000–0.000)	0.997
BMI (kg/m²)	1.496 (1.311–1.707)	< 0.001	1.148 (0.957–1.376)	0.138
Hypercholesterolemia (vs. none)	3.273 (1.018–10.523)	0.047	3.042 × e¹⁰	0.996
Smoking (vs. never)
Former	3.353 (1.653–6.803)	0.001	0.284 (0.080–1.007)	0.051
Current	16.185 (6.650–39.392)	< 0.001	2.406 (0.606–9.545)	0.212
Alcohol (vs. never)
Former	4.747 (2.055–10.964)	< 0.001	1.854 (0.383–8.965)	0.443
Current	3.048 (1.575–5.895)	0.001	0.374 (0.109–1.290)	0.119
mRNA expression levels
DDX11 (frozen tissue)	0.785 (0.726–0.850)	< 0.001	0.816 (0.706–0.943)	0.006
ISUP nuclear grade (reference low-grade)	0.070 (0.034–0.142)	< 0.001	0.245 (0.061–0.974)	0.046

^aP values determined using logistic regression for univariate analysis
^bP values determined using logistic regression for multivariate analysis. BMI body mass index

ISSN: 2049-3002