Skip to main content

Table 1 Metabolite profiling of CCA tissues

From: Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models

Metabolites Chemical shift R2 of OPLS-DA R2 of OPLS regression
Control vs cisplatin Control vs SSZ Control vs combined Tumor size of control vs combined
3-Hydroxykynurenine 3.71(d); 4.16(t); 6.71(t); 7.05(d); 7.45(d)   0.8822   
Alanine 1.48(d); 3.79(q)     
Glycerate 3.72(dd); 3.83(dd)   0.8940   
Creatine 3.04(s); 3.93(s); 4.09(dd) 0.9217 0.9039 0.8967 0.8967
Lactate 1.33(d); 4.11(q) 0.8523 0.7985   
NAD+ 4.761(t); 6.094(d); 8.239(s); 8.335(s) 0.8593    
Phospho(enol)pyruvate 5.19(t); 5.37(t) 0.9175 0.8901 0.857  
Allantoin 5.4(s) 0.8547 0.8083 0.8688 0.877
Uracil 5.81(d); 7.54(d)    − 0.6106  
Unknown-1     0.8738 0.9039
cis-Aconitate 3.17(s); 5.92(s) 0.8518    
Cytosine 5.98(d); 7.51(d) 0.8090    
Isocytosine 5.99(d); 7.62(d) 0.8894    
Inosine 3.85(dd); 3.92(dd); 4.28(q); 4.44(t); 6.1(d); 8.24(s); 8.34(s) 0.9123 0.9887 0.9754 0.9603
Orotate 6.2(s)     − 0.8591
5-Hydroxytryptophan 3.23(dd); 3.41 (dd); 4.02(dd); 6.87(d); 6.88(d); 7.14(s); 7.28(s); 7.41(d)     0.9361
Anserine 2.67(m); 3.01(dd); 3.21(m);3.21(dd);3.72(s);4.48; 6.97(s); 7.95(s)    0.8258  
p-Hydroxyphenylpyruvate 3.92(s); 6.63(d); 6.99(d); 7.73(d); 9.43(s)    0.7812  
Tryptophan 3.31(dd); 3.49(dd); 4.06(dd); 7.21(t); 7.29(t); 7.33(s); 7.55(d); 7.74(d)    − 0.8846  
Quinolinate 7.45(q); 7.9(d); 8.02(d)    − 0.7986  
N-Acetylhistamine 2.84(t); 3.45(m); 7.03(s); 7.95(s) 0.8164    
Picolinate 7.54(t); 7.92(d); 7.96(t); 8.57(s) 0.9170 0.8502 0.8232 0.8232
Phosphocreatine 3.05(s); 3.95(s) 0.8443 0.9367 0.8623 0.8835
  1. s singlet, d doublet, t triplet, q quartet, dd doublet of doublet, m multiplet