Table 1 Metabolite profiling of CCA tissues

3-Hydroxykynurenine

3.71(d); 4.16(t); 6.71(t); 7.05(d); 7.45(d)

0.8822

Alanine

1.48(d); 3.79(q)

Glycerate

3.72(dd); 3.83(dd)

0.8940

Creatine

3.04(s); 3.93(s); 4.09(dd)

0.9217

0.9039

0.8967

0.8967

Lactate

1.33(d); 4.11(q)

0.8523

0.7985

NAD⁺

4.761(t); 6.094(d); 8.239(s); 8.335(s)

0.8593

Phospho(enol)pyruvate

5.19(t); 5.37(t)

0.9175

0.8901

0.857

Allantoin

5.4(s)

0.8547

0.8083

0.8688

0.877

Uracil

5.81(d); 7.54(d)

− 0.6106

Unknown-1

0.8738

0.9039

cis-Aconitate

3.17(s); 5.92(s)

0.8518

Cytosine

5.98(d); 7.51(d)

0.8090

Isocytosine

5.99(d); 7.62(d)

0.8894

Inosine

3.85(dd); 3.92(dd); 4.28(q); 4.44(t); 6.1(d); 8.24(s); 8.34(s)

0.9123

0.9887

0.9754

0.9603

Orotate

6.2(s)

− 0.8591

5-Hydroxytryptophan

3.23(dd); 3.41 (dd); 4.02(dd); 6.87(d); 6.88(d); 7.14(s); 7.28(s); 7.41(d)

0.9361

Anserine

2.67(m); 3.01(dd); 3.21(m);3.21(dd);3.72(s);4.48; 6.97(s); 7.95(s)

0.8258

p-Hydroxyphenylpyruvate

3.92(s); 6.63(d); 6.99(d); 7.73(d); 9.43(s)

0.7812

Tryptophan

3.31(dd); 3.49(dd); 4.06(dd); 7.21(t); 7.29(t); 7.33(s); 7.55(d); 7.74(d)

− 0.8846

Quinolinate

7.45(q); 7.9(d); 8.02(d)

− 0.7986

N-Acetylhistamine

2.84(t); 3.45(m); 7.03(s); 7.95(s)

0.8164

Picolinate

7.54(t); 7.92(d); 7.96(t); 8.57(s)

0.9170

0.8502

0.8232

0.8232

Phosphocreatine

3.05(s); 3.95(s)

0.8443

0.9367

0.8623

0.8835