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Table 3 Fold change analysis reveals elevated levels of acylcarnitine species in mutant IDH chondrosarcomas

From: Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

Lipid profiling acylcarnitines Acylcarnitine length Fold change—mutant IDH1 vs non-mutant Chondrosarcoma p-value Fold change—mutant IDH2 vs non-mutant Chondrosarcoma p-value
Acetyl-CoA derivative
 C2 SC-AC 3.0 0.0510 2.8 0.1189
Amino acid derivatives—odd chain species
 C3 SC-AC 2.0 0.0430* 2.6 0.2937
 C5:1 SC-AC 3.0 0.3391 4.9 0.0087*
 C5 SC-AC 4.3 0.1445 6.3 0.3449
 C5-OH/C3-DC SC-AC 6.2 0.2576 4.0 0.1920
 C5-DC MC-AC 0.9 0.7707 1.3 0.4642
 C7-DC MC-AC 3.7 0.1326 1.7 0.5192
Fatty acid derivatives—even chain species
 C6 SC-AC 2.0 0.0842 2.2 0.2127
 C8:1 SC-AC 0.7 0.3901 1.2 0.7380
 C8 MC-AC 1.7 0.0722 1.9 0.2351
 C8:1-OH/C6:1-DC MC-AC 0.9 0.7353 1.1 0.7281
 C6-DC/C8-OH MC-AC 2.0 0.1644 2.8 0.0969
 C10:3 MC-AC 1.0 0.9255 1.1 0.8489
 C10:2 MC-AC 1.1 0.8987 1.6 0.4553
 C10:1 MC-AC 1.3 0.4115 0.9 0.7575
 C10 MC-AC 2.9 0.0162* 2.0 0.2869
 C8:1-DC MC-AC 1.6 0.5332 0.7 0.7576
 C10-OH/C8-DC MC-AC 0.8 0.6839 0.6 0.2910
 C12:1 MC-AC 1.9 0.4518 2.2 0.0732
 C12 MC-AC 1.6 0.2373 1.3 0.7066
 C12-OH/C10-DC MC-AC 0.6 0.3945 0.9 0.8496
 C14:2 LC-AC 1.1 0.7881 1.0 0.9626
 C14:1 LC-AC 1.9 0.0985 1.7 0.5002
 C14 LC-AC 1.8 0.1588 2.2 0.3238
 C14:1-OH LC-AC 2.1 0.2333 2.3 0.2990
 C14-OH/C12-DC LC-AC 1.1 0.7262 0.8 0.6335
 C16:2 LC-AC 1.2 0.6409 1.2 0.7771
 C16:1 LC-AC 3.1 0.0675 2.6 0.3013
 C16 LC-AC 3.3 0.0164* 4.1 0.2330
 C16:1-OH/C14:1-DC LC-AC 2.6 0.0313* 4.5 0.3420
 C16-OH/C14-DC LC-AC 1.4 0.5234 1.8 0.3100
 C18:2 LC-AC 2.4 0.2108 3.3 0.3426
 C18:1 LC-AC 3.3 0.0734 2.9 0.3638
 C18 LC-AC 4.8 0.1059 6.0 0.3753
 C18:2-OH LC-AC 1.3 0.4134 1.6 0.6317
 C18:1-OH/C16:1-DC LC-AC 2.0 0.1328 3.6 0.3811
 C18-OH/C16-DC LC-AC 1.9 0.1788 4.6 0.4159
 C20:4 LC-AC 2.9 0.0293* 2.4 0.0883
 C20 VLC-AC 3.2 0.1964 24.6 0.4088
 C18:1-DC VLC-AC 3.3 0.0861 9.9 0.3591
 C20-OH/C18-DC VLC-AC 2.8 0.1026 7.0 0.2104
 C22 VLC-AC 1.3 0.5074 15.7 0.4142
Amino acid & fatty acid derivatives
 C4/Ci4 SC-AC 5.9 0.1180 3.7 0.0602
 C4-OH SC-AC 2.9 0.0676 3.4 0.0193*
 C4-DC/Ci4-DC SC-AC 1.0 0.9681 1.2 0.7348
  1. p-value = t-test p < 0.05, italic, bold: significant in t-test
  2. SC-AC short-chain acylcarnitine
  3. MC-AC medium-chain acylcarnitine
  4. LC-AC long-chain acylcarnitine
  5. VLC-AC very-long-chain acylcarnitine