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Table 2 Fold change analysis reveals global elevation of amino acids in mutant IDH chondrosarcomas in comparison with non-mutant chondrosarcomas

From: Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

Amino acid Fold change—mutant IDH1 vs non-mutant Chondrosarcoma p-value Fold change—mutant IDH2 vs non-mutant Chondrosarcoma p-value
Glucogenic amino acids
 Val 2.8 0.0015* 3.6 0.1275
 Met 2.7 0.0156* 4.5 0.1989
 His 2.6 0.0071* 3.4 0.0703
 Arg 1.5 0.1729 3.8 0.3309
 Gly 3.1 0.0174* 3.4 0.0497*
 Gln 2.8 0.0950 3.7 0.0222*
 Pro 4.5 0.0021* 5.7 0.0404*
 Ser 2.8 0.0502* 4.5 0.0487*
 Asp 4.0 0.0639 5.8 0.0125*
 Asn 3.0 0.0340* 6.0 0.1083
 Ala 3.4 0.0080* 3.2 0.0659
 Glu 3.2 0.0680 4.3 0.0594
Ketogenic amino acids
 Leu/ Ile 3.2 0.0021* 4.8 0.1097
Glucogenic & ketogenic amino acids
 Phe 3.3 0.0099* 4.9 0.1459
 Tyr 3.3 0.0068* 4.5 0.1403
Other amino acids
 Orn 2.0 0.0128* 1.5 0.2156
 Cit 2.8 0.0667 2.8 0.1950
  1. p-value = t-test p < 0.05, italic, bold: significant in t-test