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Table 2 Fold change analysis reveals global elevation of amino acids in mutant IDH chondrosarcomas in comparison with non-mutant chondrosarcomas

From: Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

Amino acid

Fold change—mutant IDH1 vs non-mutant Chondrosarcoma

p-value

Fold change—mutant IDH2 vs non-mutant Chondrosarcoma

p-value

Glucogenic amino acids

 Val

2.8

0.0015*

3.6

0.1275

 Met

2.7

0.0156*

4.5

0.1989

 His

2.6

0.0071*

3.4

0.0703

 Arg

1.5

0.1729

3.8

0.3309

 Gly

3.1

0.0174*

3.4

0.0497*

 Gln

2.8

0.0950

3.7

0.0222*

 Pro

4.5

0.0021*

5.7

0.0404*

 Ser

2.8

0.0502*

4.5

0.0487*

 Asp

4.0

0.0639

5.8

0.0125*

 Asn

3.0

0.0340*

6.0

0.1083

 Ala

3.4

0.0080*

3.2

0.0659

 Glu

3.2

0.0680

4.3

0.0594

Ketogenic amino acids

 Leu/ Ile

3.2

0.0021*

4.8

0.1097

Glucogenic & ketogenic amino acids

 Phe

3.3

0.0099*

4.9

0.1459

 Tyr

3.3

0.0068*

4.5

0.1403

Other amino acids

 Orn

2.0

0.0128*

1.5

0.2156

 Cit

2.8

0.0667

2.8

0.1950

  1. p-value = t-test p < 0.05, italic, bold: significant in t-test