Fig. 8
From: The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
The PD-L1 metabolic interactome intersects with choline metabolism and inflammation. The inverse interdependence between PD-L1 and Chk-α together with the changes in metabolites with PD-L1 and Chk-α downregulation is summarized. Metabolites displayed in red are associated with PD-L1 regulation (glutamate, pyruvate, lactate, and glutamine), those in orange are related to creating an immune suppressive microenvironment (MTA, adenosine), those in purple are associated with escape from immune surveillance (PC) and lipids, highlighted in blue, skew tumor-infiltrating myeloid cells towards immunosuppressive and anti-inflammatory phenotypes