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Fig. 3 | Cancer & Metabolism

Fig. 3

From: RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

Fig. 3

Function of RNF115 expression on xenograft growth in mice. ae Comparison of RNF115 expression and xenograft status between mice (n = 5 per group) subcutaneously injected with H358 cells stably expressing shRNF115 (1#) and control shRNA (NC). a Tumor volume growth in mice after injection. b Image and comparison of the xenografts at day 33. c Tumor weights at day 33. d Expression of RNF115 protein in the xenografts at day 33 by western blotting with the loading control as GAPDH. e Visualization and analysis of the apoptotic cells in the xenografts at day 33 by TUNEL. Images at × 200 magnification. *P < 0.05, **P < 0.01, and ***P < 0.001 vs NC. fj Comparison of RNF115 expression and xenograft status between mice (n = 5 per group) subcutaneously injected with H1299 cells stably expressing RNF115 (oRNF115) and control (Vector). f Tumor volume growth in mice after injection. g Image and comparison of the xenografts at day 33. h Tumor weights at day 33. i Expression of RNF115 protein in the xenografts at day 33 by western blotting. GAPDH as loading control. j Visualization and analysis of the apoptotic cells in the xenografts at day 33 by TUNEL. Images at × 200 magnification. *P < 0.05, **P < 0.01, and ***P < 0.001 vs Vector

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