Table 1 Identified and significantly different masses between cancer and non-cancer epithelium after univariate linear mixed models testing. Log2 fold change (Log2FC) is reported comparing cancer to non-cancer epithelium. ‘ID in OPLS-DA’ can be used to find the analyte on the loadings plot in Fig. 2. The reported m/z values are from MALDI-TOF measurements. LPC = lysophospatidylcholine, PE = phosphatidylethanolamine, and PS = phosphatidylserine
From: Spatial differentiation of metabolism in prostate cancer tissue by MALDI-TOF MSI
m/z MALDI-TOF | ID | ID in OPLS-DA | Log2FC | p value |
|---|---|---|---|---|
104.17 | Choline | Choline | 0.785 | 9.6 × 10−4 |
132. 03 | Aspartate | Aspartate | − 0.579 | 2.5 × 10−6 |
146.17 | Acetylcholine | ACho | 0.537 | 5.1 × 10−4 |
162.16 | Carnitine | Carnitine | 0.747 | 2.3 × 10−9 |
167.03 | Urate | Urate | 0.290 | 2.2 × 10−3 |
174.83* | Zinc (ZnCl3−) | Zinc | − 1.054 | 1.9 × 10−4 |
175.02** | Ascorbate/Glucurone | Ascorbate | − 0.281 | 0.010 |
191.02 | Citrate | Citrate | − 0.892 | 2.3 × 10−7 |
204.17 | Acetylcarnitine | Acetylcarnitine | 0.789 | 1.7 × 10−4 |
248.19 | Hydroxybutyrylcarnitine | HBCt | 0.888 | 1.0 × 10−3 |
426.01 | Adenosine diphosphate | ADP | 0.387 | 0.025 |
518.37 | LPC (16:0) | LPC 82 | − 1.384 | 7.8 × 10−6 |
534.34 | LPC (16:0) | LPC 86 | − 1.168 | 1.6 × 10−5 |
544.39 | LPC (18:1) | LPC 90 | − 0.744 | 1.0 × 10−4 |
792.53 | PE (20:1_20:4) | PE 112 | 0.590 | 0.041 |
838.51 | PS (40:4) | PS 124 | 0.326 | 8.8 × 10−3 |