TY - JOUR AU - Balogh, J. AU - Victor, D. AU - Asham, E. AU - Borroughs, S. G. AU - Boktour, M. AU - Saharia, A. PY - 2016 DA - 2016// TI - Hepatocellular carcinoma: a review JO - J Hepatocell Carcinoma. VL - 3 UR - https://doi.org/10.2147/JHC.S61146 DO - 10.2147/JHC.S61146 ID - Balogh2016 ER - TY - JOUR AU - Flores, A. AU - Marrero, J. A. PY - 2014 DA - 2014// TI - Emerging trends in hepatocellular carcinoma: focus on diagnosis and therapeutics JO - Clin Med Insights Oncol. VL - 8 UR - https://doi.org/10.4137/CMO.S9926 DO - 10.4137/CMO.S9926 ID - Flores2014 ER - TY - JOUR AU - Valter, K. AU - Maximchik, P. AU - Abdrakhmanov, A. AU - Senichkin, V. AU - Zhivotovsky, B. AU - Gogvadze, V. PY - 2020 DA - 2020// TI - Distinct effects of etoposide on glutamine-addicted neuroblastoma JO - Cell Mol Life Sci. VL - 77 UR - https://doi.org/10.1007/s00018-019-03232-z DO - 10.1007/s00018-019-03232-z ID - Valter2020 ER - TY - JOUR AU - Kuznetsov, A. V. AU - Margreiter, R. AU - Amberger, A. AU - Saks, V. AU - Grimm, M. PY - 1813 DA - 1813// TI - Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death JO - Biochim Biophys Acta - Mol Cell Res. VL - 2011 ID - Kuznetsov1813 ER - TY - JOUR AU - Rodríguez-Hernández, M. A. AU - Cruz-Ojeda, P. AU - Gallego, P. AU - Navarro-Villarán, E. AU - Staňková, P. AU - Campo, J. A. PY - 2020 DA - 2020// TI - Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells JO - Biochem Pharmacol VL - 176 UR - https://doi.org/10.1016/j.bcp.2020.113902 DO - 10.1016/j.bcp.2020.113902 ID - Rodríguez-Hernández2020 ER - TY - JOUR AU - Gohil, V. M. AU - Sheth, S. A. AU - Nilsson, R. AU - Wojtovich, A. P. AU - Lee, J. H. AU - Perocchi, F. PY - 2010 DA - 2010// TI - Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis JO - Nat Biotechnol. VL - 28 UR - https://doi.org/10.1038/nbt.1606 DO - 10.1038/nbt.1606 ID - Gohil2010 ER - TY - JOUR AU - Chen, F. AU - Fang, Y. AU - Zhao, R. AU - Le, J. AU - Zhang, B. AU - Huang, R. PY - 2019 DA - 2019// TI - Evolution in medicinal chemistry of sorafenib derivatives for hepatocellular carcinoma JO - Eur J Med Chem. VL - 179 UR - https://doi.org/10.1016/j.ejmech.2019.06.070 DO - 10.1016/j.ejmech.2019.06.070 ID - Chen2019 ER - TY - JOUR AU - Heindryckx, F. AU - Colle, I. AU - Vlierberghe, H. PY - 2009 DA - 2009// TI - Experimental mouse models for hepatocellular carcinoma research JO - Int J Exp Pathol. VL - 90 UR - https://doi.org/10.1111/j.1365-2613.2009.00656.x DO - 10.1111/j.1365-2613.2009.00656.x ID - Heindryckx2009 ER - TY - JOUR AU - Ong, L. C. AU - Song, I. C. AU - Jin, Y. AU - Kee, I. H. C. AU - Siew, E. AU - Yu, S. PY - 2009 DA - 2009// TI - Effective inhibition of xenografts of hepatocellular carcinoma (hepg2) by rapamycin and bevacizumab in an intrahepatic model JO - Mol Imaging Biol. VL - 11 UR - https://doi.org/10.1007/s11307-009-0213-4 DO - 10.1007/s11307-009-0213-4 ID - Ong2009 ER - TY - JOUR AU - Subramaniam, A. AU - Shanmugam, M. K. AU - Ong, T. H. AU - Li, F. AU - Perumal, E. AU - Chen, L. PY - 2013 DA - 2013// TI - Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3 JO - Br J Pharmacol. VL - 170 UR - https://doi.org/10.1111/bph.12302 DO - 10.1111/bph.12302 ID - Subramaniam2013 ER - TY - JOUR AU - Zhang, X. D. AU - Deslandes, E. AU - Villedieu, M. AU - Poulain, L. AU - Duval, M. AU - Gauduchon, P. PY - 2006 DA - 2006// TI - Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro JO - Anticancer Res VL - 26 5 A ID - Zhang2006 ER - TY - JOUR AU - Desquiret, V. AU - Loiseau, D. AU - Jacques, C. AU - Douay, O. AU - Malthièry, Y. AU - Ritz, P. PY - 1757 DA - 1757// TI - Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells JO - Biochim Biophys Acta - Bioenerg. VL - 2006 ID - Desquiret1757 ER - TY - JOUR AU - Periera da Silva, A. P. AU - El-Bacha, T. AU - Kyaw, N. AU - Santosa, R. S. AU - da-Silva, W. S. AU - Almeida, F. C. PY - 2009 DA - 2009// TI - Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate JO - Biochem J VL - 417 UR - https://doi.org/10.1042/BJ20080805 DO - 10.1042/BJ20080805 ID - Periera da Silva2009 ER - TY - JOUR AU - Xiao, Z. AU - Dai, Z. AU - Locasale, J. W. PY - 2019 DA - 2019// TI - Metabolic landscape of the tumor microenvironment at single cell resolution JO - Nat Commun. VL - 10 UR - https://doi.org/10.1038/s41467-019-11738-0 DO - 10.1038/s41467-019-11738-0 ID - Xiao2019 ER - TY - JOUR AU - Robinson, B. H. AU - Petrova-Benedict, R. AU - Buncic, J. R. AU - Wallace, D. C. PY - 1992 DA - 1992// TI - Nonviability of cells with oxidative defects in galactose medium: a screening test for affected patient fibroblasts JO - Biochem Med Metab Biol. VL - 48 UR - https://doi.org/10.1016/0885-4505(92)90056-5 DO - 10.1016/0885-4505(92)90056-5 ID - Robinson1992 ER - TY - STD TI - Selenius LA, Lundgren MW, Jawad R, Danielsson O, Björnstedt M. The cell culture medium affects growth, phenotype expression and the response to selenium cytotoxicity in A549 and Hepg2 cells. Antioxidants. 2019;8:130. ID - ref16 ER - TY - JOUR AU - Dykens, J. A. AU - Jamieson, J. AU - Marroquin, L. AU - Nadanaciva, S. AU - Billis, P. A. AU - Will, Y. PY - 2008 DA - 2008// TI - Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro JO - Toxicol Appl Pharmacol. VL - 233 UR - https://doi.org/10.1016/j.taap.2008.08.013 DO - 10.1016/j.taap.2008.08.013 ID - Dykens2008 ER - TY - JOUR AU - Marroquin, L. D. AU - Hynes, J. AU - Dykens, J. A. AU - Jamieson, J. D. AU - Will, Y. PY - 2007 DA - 2007// TI - Circumventing the crabtree effect: Replacing media glucose with galactose increases susceptibility of hepG2 cells to mitochondrial toxicants JO - Toxicol Sci. VL - 97 UR - https://doi.org/10.1093/toxsci/kfm052 DO - 10.1093/toxsci/kfm052 ID - Marroquin2007 ER - TY - JOUR AU - Hugo-Wissemann, D. AU - Anundi, I. AU - Lauchart, W. AU - Viebahn, R. AU - Groot, H. PY - 1991 DA - 1991// TI - Differences in glycolytic capacity and hypoxia tolerance between hepatoma cells and hepatocytes JO - Hepatology. VL - 13 UR - https://doi.org/10.1002/hep.1840130215 DO - 10.1002/hep.1840130215 ID - Hugo-Wissemann1991 ER - TY - JOUR AU - Fiume, L. AU - Manerba, M. AU - Vettraino, M. AU - Stefano, G. PY - 2010 DA - 2010// TI - Impairment of aerobic glycolysis by inhibitors of lactic dehydrogenase hinders the growth of human hepatocellular carcinoma cell lines JO - Pharmacology. VL - 86 UR - https://doi.org/10.1159/000317519 DO - 10.1159/000317519 ID - Fiume2010 ER - TY - JOUR AU - Nakajima, K. AU - Yamauchi, K. AU - Shigematsu, S. AU - Ikeo, S. AU - Komatsu, M. AU - Aizawa, T. PY - 2000 DA - 2000// TI - Selective attenuation of metabolic branch of insulin receptor down- signaling by high glucose in a hepatoma cell line, HepG2 cells JO - J Biol Chem. VL - 275 UR - https://doi.org/10.1074/jbc.M905410199 DO - 10.1074/jbc.M905410199 ID - Nakajima2000 ER - TY - JOUR AU - Loiseau, D. AU - Morvan, D. AU - Chevrollier, A. AU - Demidem, A. AU - Douay, O. AU - Reynier, P. PY - 2009 DA - 2009// TI - Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy JO - Mol Carcinog. VL - 48 UR - https://doi.org/10.1002/mc.20539 DO - 10.1002/mc.20539 ID - Loiseau2009 ER - TY - STD TI - Knowles BB, Aden DP. A human hepatoma derived cell line, process for preparation thereof, and uses therefore: United States Patent US4393133A; 1983. ID - ref23 ER - TY - JOUR AU - Dai, Q. AU - Yin, Y. AU - Liu, W. AU - Wei, L. AU - Zhou, Y. AU - Li, Z. PY - 2013 DA - 2013// TI - Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells JO - Int J Biochem Cell Biol. VL - 45 UR - https://doi.org/10.1016/j.biocel.2013.04.015 DO - 10.1016/j.biocel.2013.04.015 ID - Dai2013 ER - TY - JOUR AU - Domenis, R. AU - Bisetto, E. AU - Rossi, D. AU - Comelli, M. AU - Mavelli, I. PY - 2012 DA - 2012// TI - Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and Inhibitor Factor 1 JO - Int J Mol Sci. VL - 13 UR - https://doi.org/10.3390/ijms13021933 DO - 10.3390/ijms13021933 ID - Domenis2012 ER - TY - JOUR AU - Domenis, R. AU - Comelli, M. AU - Bisetto, E. AU - Mavelli, I. PY - 2011 DA - 2011// TI - Mitochondrial bioenergetic profile and responses to metabolic inhibition in human hepatocarcinoma cell lines with distinct differentiation characteristics JO - J Bioenerg Biomembr. VL - 43 UR - https://doi.org/10.1007/s10863-011-9380-5 DO - 10.1007/s10863-011-9380-5 ID - Domenis2011 ER - TY - JOUR AU - WNP, L. AU - Boros, L. G. AU - Puigjaner, J. AU - Bassilian, S. AU - Lim, S. AU - Cascante, M. PY - 1998 DA - 1998// TI - Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose JO - Am J Physiol - Endocrinol Metab VL - 274 5 37-5 ID - WNP1998 ER - TY - JOUR AU - Dalmonte, M. E. AU - Forte, E. AU - Genova, M. L. AU - Giuffrè, A. AU - Sarti, P. AU - Lenaz, G. PY - 2009 DA - 2009// TI - Control of respiration by cytochrome c oxidase in intact cells: role of the membrane potential JO - J Biol Chem. VL - 284 UR - https://doi.org/10.1074/jbc.M109.050146 DO - 10.1074/jbc.M109.050146 ID - Dalmonte2009 ER - TY - JOUR AU - Schneider, C. A. AU - Rasband, W. S. AU - Eliceiri, K. W. PY - 2012 DA - 2012// TI - NIH Image to ImageJ: 25 years of image analysis JO - Nat Methods. VL - 9 UR - https://doi.org/10.1038/nmeth.2089 DO - 10.1038/nmeth.2089 ID - Schneider2012 ER - TY - JOUR AU - Zamponi, N. AU - Zamponi, E. AU - Cannas, S. A. AU - Billoni, O. V. AU - Helguera, P. R. AU - Chialvo, D. R. PY - 2018 DA - 2018// TI - Mitochondrial network complexity emerges from fission/fusion dynamics JO - Sci Rep. VL - 8 UR - https://doi.org/10.1038/s41598-017-18351-5 DO - 10.1038/s41598-017-18351-5 ID - Zamponi2018 ER - TY - JOUR AU - Koopman, W. J. H. AU - Verkaart, S. AU - Visch, H. J. AU - Westhuizen, F. H. AU - Murphy, M. P. AU - Heuvel, L. W. P. J. PY - 2005 DA - 2005// TI - Inhibition of complex I of the electron transport chain causes O 2-.-mediated mitochondrial outgrowth JO - Am J Physiol - Cell Physiol VL - 288 6 57-6 UR - https://doi.org/10.1152/ajpcell.00607.2004 DO - 10.1152/ajpcell.00607.2004 ID - Koopman2005 ER - TY - JOUR AU - Sage, D. AU - Donati, L. AU - Soulez, F. AU - Fortun, D. AU - Schmit, G. AU - Seitz, A. PY - 2017 DA - 2017// TI - DeconvolutionLab2: an open-source software for deconvolution microscopy JO - Methods. VL - 115 UR - https://doi.org/10.1016/j.ymeth.2016.12.015 DO - 10.1016/j.ymeth.2016.12.015 ID - Sage2017 ER - TY - JOUR AU - Lemasters, J. J. AU - Ramshesh, V. K. PY - 2007 DA - 2007// TI - Imaging of mitochondrial polarization and depolarization with cationic fluorophores JO - Methods Cell Biol. VL - 80 UR - https://doi.org/10.1016/S0091-679X(06)80014-2 DO - 10.1016/S0091-679X(06)80014-2 ID - Lemasters2007 ER - TY - JOUR AU - Scaduto, R. C. AU - Grotyohann, L. W. PY - 1999 DA - 1999// TI - Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives JO - Biophys J VL - 76 1 I UR - https://doi.org/10.1016/S0006-3495(99)77214-0 DO - 10.1016/S0006-3495(99)77214-0 ID - Scaduto1999 ER - TY - JOUR AU - Ward, M. W. AU - Rego, A. C. AU - Frenguelli, B. G. AU - Nicholls, D. G. PY - 2000 DA - 2000// TI - Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells JO - J Neurosci. VL - 20 UR - https://doi.org/10.1523/JNEUROSCI.20-19-07208.2000 DO - 10.1523/JNEUROSCI.20-19-07208.2000 ID - Ward2000 ER - TY - STD TI - Gnaiger E. Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis: 4th ed. Mitochondrial Physiology Network 19.12. Innsbruck: OROBOROS MiPNet Publications; 2014. ID - ref36 ER - TY - JOUR AU - Glancy, B. AU - Willis, W. T. AU - Chess, D. J. AU - Balaban, R. S. PY - 2013 DA - 2013// TI - Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria JO - Biochemistry. VL - 52 UR - https://doi.org/10.1021/bi3015983 DO - 10.1021/bi3015983 ID - Glancy2013 ER - TY - JOUR AU - Messer, J. I. AU - Jackman, M. R. AU - Willis, W. T. PY - 2004 DA - 2004// TI - Pyruvate and citric acid cycle carbon requirements in isolated skeletal muscle mitochondria JO - Am J Physiol - Cell Physiol VL - 286 UR - https://doi.org/10.1152/ajpcell.00146.2003 DO - 10.1152/ajpcell.00146.2003 ID - Messer2004 ER - TY - STD TI - Connett RJ. Analysis of metabolic control: new insights using scaled creatine kinase model. Am J Physiol - Regul Integr Comp Physiol. 1988;254:R949-59. ID - ref39 ER - TY - JOUR AU - Fisher-Wellman, K. H. AU - Davidson, M. T. AU - Narowski, T. M. AU - Te, L. C. AU - Koves, T. R. AU - Muoio, D. M. PY - 2018 DA - 2018// TI - Mitochondrial diagnostics: a multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes JO - Cell Rep VL - 24 UR - https://doi.org/10.1016/j.celrep.2018.08.091 DO - 10.1016/j.celrep.2018.08.091 ID - Fisher-Wellman2018 ER - TY - JOUR AU - Lark, D. S. AU - Torres, M. J. AU - Lin, C. AU - Ryan, T. E. AU - Anderson, E. J. AU - Neufer, P. D. PY - 2016 DA - 2016// TI - Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers JO - Am J Physiol - Cell Physiol. VL - 311 UR - https://doi.org/10.1152/ajpcell.00124.2016 DO - 10.1152/ajpcell.00124.2016 ID - Lark2016 ER - TY - JOUR AU - Reily, C. AU - Mitchell, T. AU - Chacko, B. K. AU - Benavides, G. A. AU - Murphy, M. P. AU - Darley-Usmar, V. M. PY - 2013 DA - 2013// TI - Mitochondrially targeted compounds and their impact on cellular bioenergetics JO - Redox Biol. VL - 1 UR - https://doi.org/10.1016/j.redox.2012.11.009 DO - 10.1016/j.redox.2012.11.009 ID - Reily2013 ER - TY - JOUR AU - Mookerjee, S. A. AU - Goncalves, R. L. S. AU - Gerencser, A. A. AU - Nicholls, D. G. AU - Brand, M. D. PY - 1847 DA - 1847// TI - The contributions of respiration and glycolysis to extracellular acid production JO - Biochim Biophys Acta - Bioenerg. VL - 2015 ID - Mookerjee1847 ER - TY - JOUR AU - Mookerjee, S. A. AU - Gerencser, A. A. AU - Nicholls, D. G. AU - Brand, M. D. PY - 2017 DA - 2017// TI - Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements JO - J Biol Chem. VL - 292 UR - https://doi.org/10.1074/jbc.M116.774471 DO - 10.1074/jbc.M116.774471 ID - Mookerjee2017 ER - TY - JOUR AU - Vilà-Brau, A. AU - Sousa-Coelho, A. L. AU - Mayordomo, C. AU - Haro, D. AU - Marrero, P. F. PY - 2011 DA - 2011// TI - Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line JO - J Biol Chem. VL - 286 UR - https://doi.org/10.1074/jbc.M111.235044 DO - 10.1074/jbc.M111.235044 ID - Vilà-Brau2011 ER - TY - JOUR AU - Gibbons, G. F. AU - Khurana, R. AU - Odwell, A. AU - Seclaender, M. C. L. PY - 1994 DA - 1994// TI - Lipid balance in HepG2 cells: active synthesis and impaired mobilization JO - J Lipid Res. VL - 35 UR - https://doi.org/10.1016/S0022-2275(20)39775-3 DO - 10.1016/S0022-2275(20)39775-3 ID - Gibbons1994 ER - TY - JOUR AU - Mookerjee, S. A. AU - Nicholls, D. G. AU - Brand, M. D. PY - 2016 DA - 2016// TI - Determining maximum glycolytic capacity using extracellular flux measurements JO - PLoS One. VL - 11 UR - https://doi.org/10.1371/journal.pone.0152016 DO - 10.1371/journal.pone.0152016 ID - Mookerjee2016 ER - TY - JOUR AU - Erecinska, M. AU - Dagani, F. AU - Nelson, D. AU - Deas, J. AU - Silver, I. A. PY - 1991 DA - 1991// TI - Relations between intracellular ions and energy metabolism: a study with monensin in synaptosomes, neurons, and C6 glioma cells JO - J Neurosci. VL - 11 UR - https://doi.org/10.1523/JNEUROSCI.11-08-02410.1991 DO - 10.1523/JNEUROSCI.11-08-02410.1991 ID - Erecinska1991 ER - TY - JOUR AU - O’Brien, J. AU - Wilson, I. AU - Orton, T. AU - Pognan, F. PY - 2000 DA - 2000// TI - Investigation of Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity JO - Eur Biochem VL - 5426 UR - https://doi.org/10.1046/j.1432-1327.2000.01606.x DO - 10.1046/j.1432-1327.2000.01606.x ID - O’Brien2000 ER - TY - STD TI - Reitzer LJ, Wice BM, Kennell D. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 1979;254:2669–76. ID - ref50 ER - TY - JOUR AU - Xu, Q. AU - Liu, L. AU - Vu, H. AU - Kuhls, M. AU - Aslamkhan, A. G. AU - Liaw, A. PY - 2019 DA - 2019// TI - Can galactose be converted to glucose in HepG2 cells? Improving the in vitro mitochondrial toxicity assay for the assessment of drug induced liver injury JO - Chem Res Toxicol. VL - 32 UR - https://doi.org/10.1021/acs.chemrestox.9b00033 DO - 10.1021/acs.chemrestox.9b00033 ID - Xu2019 ER - TY - JOUR AU - Koopman, W. J. H. AU - Visch, H. J. AU - Verkaart, S. AU - Heuvel, L. W. P. J. AU - Smeitink, J. A. M. AU - Willems, P. H. G. M. PY - 2005 DA - 2005// TI - Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency JO - Am J Physiol - Cell Physiol VL - 289 UR - https://doi.org/10.1152/ajpcell.00104.2005 DO - 10.1152/ajpcell.00104.2005 ID - Koopman2005 ER - TY - JOUR AU - Yang, C. AU - Ko, B. AU - Hensley, C. T. AU - Jiang, L. AU - Wasti, A. T. AU - Kim, J. PY - 2014 DA - 2014// TI - Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport JO - Mol Cell. VL - 56 UR - https://doi.org/10.1016/j.molcel.2014.09.025 DO - 10.1016/j.molcel.2014.09.025 ID - Yang2014 ER - TY - JOUR AU - Brand, M. D. AU - Nicholls, D. G. PY - 2011 DA - 2011// TI - Assessing mitochondrial dysfunction in cells JO - Biochem J. VL - 435 UR - https://doi.org/10.1042/BJ20110162 DO - 10.1042/BJ20110162 ID - Brand2011 ER - TY - STD TI - Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, et al. The human serum metabolome. PLoS One. 2011;6(2):e16957. ID - ref55 ER - TY - JOUR AU - Andrzejewski, S. AU - Gravel, S. -. P. AU - Pollak, M. AU - St-Pierre, J. PY - 2014 DA - 2014// TI - Metformin directly acts on mitochondria to alter cellular bioenergetics JO - Cancer Metab. VL - 2 UR - https://doi.org/10.1186/2049-3002-2-12 DO - 10.1186/2049-3002-2-12 ID - Andrzejewski2014 ER - TY - JOUR AU - Liu, X. AU - Romero, I. L. AU - Litchfield, L. M. AU - Lengyel, E. AU - Locasale, J. W. PY - 2016 DA - 2016// TI - Metformin targets central carbon metabolism and reveals mitochondrial requirements in human cancers JO - Cell Metab. VL - 24 UR - https://doi.org/10.1016/j.cmet.2016.09.005 DO - 10.1016/j.cmet.2016.09.005 ID - Liu2016 ER - TY - JOUR AU - Bridges, H. R. AU - Jones, A. J. Y. AU - Pollak, M. N. AU - Hirst, J. PY - 2014 DA - 2014// TI - Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria JO - Biochem J. VL - 462 UR - https://doi.org/10.1042/BJ20140620 DO - 10.1042/BJ20140620 ID - Bridges2014 ER - TY - JOUR AU - Frei, B. AU - Winterhalter, K. H. AU - Richter, C. PY - 1986 DA - 1986// TI - Menadione-(2-methyl-1,4-naphthoquinone-) dependent enzymatic redox cycling and calcium release by mitochondria JO - Biochemistry. VL - 25 UR - https://doi.org/10.1021/bi00363a040 DO - 10.1021/bi00363a040 ID - Frei1986 ER - TY - JOUR AU - Ježek, J. AU - Plecitá-Hlavatá, L. AU - Ježek, P. PY - 2018 DA - 2018// TI - Aglycemic HepG2 cells switch from aminotransferase glutaminolytic pathway of pyruvate utilization to complete Krebs cycle at hypoxia JO - Front Endocrinol (Lausanne). VL - 9 UR - https://doi.org/10.3389/fendo.2018.00637 DO - 10.3389/fendo.2018.00637 ID - Ježek2018 ER - TY - JOUR AU - Plecitá-Hlavatá, L. AU - Ježek, J. AU - Ježek, P. PY - 2015 DA - 2015// TI - Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells JO - J Bioenerg Biomembr. VL - 47 UR - https://doi.org/10.1007/s10863-015-9628-6 DO - 10.1007/s10863-015-9628-6 ID - Plecitá-Hlavatá2015 ER - TY - JOUR AU - Krycer, J. R. AU - Quek, L. E. AU - Francis, D. AU - Zadoorian, A. AU - Weiss, F. C. AU - Cooke, K. C. PY - 2020 DA - 2020// TI - Insulin signaling requires glucose to promote lipid anabolism in adipocytes JO - J Biol Chem. VL - 295 UR - https://doi.org/10.1074/jbc.RA120.014907 DO - 10.1074/jbc.RA120.014907 ID - Krycer2020 ER - TY - JOUR AU - Tang, M. AU - Etokidem, E. AU - Lai, K. PY - 2016 DA - 2016// TI - The leloir pathway of galactose metabolism - a novel therapeutic target for hepatocellular carcinoma JO - Anticancer Res. VL - 36 UR - https://doi.org/10.21873/anticanres.11221 DO - 10.21873/anticanres.11221 ID - Tang2016 ER - TY - JOUR AU - Rossignol, R. AU - Gilkerson, R. AU - Aggeler, R. AU - Yamagata, K. AU - Remington, S. J. AU - Capaldi, R. A. PY - 2004 DA - 2004// TI - Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells JO - Cancer Res. VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-03-1101 DO - 10.1158/0008-5472.CAN-03-1101 ID - Rossignol2004 ER - TY - JOUR AU - Tanner, L. B. AU - Goglia, A. G. AU - Wei, M. H. AU - Sehgal, T. AU - Parsons, L. R. AU - Park, J. O. PY - 2018 DA - 2018// TI - Four key steps control glycolytic flux in mammalian cells JO - Cell Syst VL - 7 UR - https://doi.org/10.1016/j.cels.2018.06.003 DO - 10.1016/j.cels.2018.06.003 ID - Tanner2018 ER - TY - JOUR AU - Diaz-Ruiz, R. AU - Rigoulet, M. AU - Devin, A. PY - 1807 DA - 1807// TI - The Warburg and Crabtree effects: on the origin of cancer cell energy metabolism and of yeast glucose repression JO - Biochim Biophys Acta - Bioenerg. VL - 2011 ID - Diaz-Ruiz1807 ER - TY - JOUR AU - Willis, W. T. AU - Jackman, M. R. AU - Messer, J. I. AU - Kuzmiak-Glancy, S. AU - Glancy, B. PY - 2016 DA - 2016// TI - A simple hydraulic analog model of oxidative phosphorylation JO - Med Sci Sports Exerc. VL - 48 UR - https://doi.org/10.1249/MSS.0000000000000884 DO - 10.1249/MSS.0000000000000884 ID - Willis2016 ER - TY - JOUR AU - Bertram, K. AU - Valcu, C. M. AU - Weitnauer, M. AU - Linne, U. AU - Görlach, A. PY - 2015 DA - 2015// TI - NOX1 supports the metabolic remodeling of HepG2 cells JO - PLoS One. VL - 10 UR - https://doi.org/10.1371/journal.pone.0122002 DO - 10.1371/journal.pone.0122002 ID - Bertram2015 ER - TY - JOUR AU - Kamalian, L. AU - Chadwick, A. E. AU - Bayliss, M. AU - French, N. S. AU - Monshouwer, M. AU - Snoeys, J. PY - 2015 DA - 2015// TI - The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death JO - Toxicol Vitr. VL - 29 UR - https://doi.org/10.1016/j.tiv.2015.02.011 DO - 10.1016/j.tiv.2015.02.011 ID - Kamalian2015 ER - TY - JOUR AU - Terashima, J. AU - Habano, W. AU - Gamou, T. AU - Ozawa, S. PY - 2011 DA - 2011// TI - Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR JO - Drug Metab Pharmacokinet. VL - 26 UR - https://doi.org/10.2133/dmpk.DMPK-11-RG-054 DO - 10.2133/dmpk.DMPK-11-RG-054 ID - Terashima2011 ER - TY - JOUR AU - Epstein, T. AU - Xu, L. AU - Gillies, R. J. AU - Gatenby, R. A. PY - 2014 DA - 2014// TI - Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane JO - Cancer Metab. VL - 2 UR - https://doi.org/10.1186/2049-3002-2-7 DO - 10.1186/2049-3002-2-7 ID - Epstein2014 ER - TY - JOUR AU - Ozdemir, T. AU - Nar, R. AU - Kilinc, V. AU - Alacam, H. AU - Salis, O. AU - Duzgun, A. PY - 2012 DA - 2012// TI - Ouabain targets the unfolded protein response for selective killing of HepG2 cells during glucose deprivation JO - Cancer Biother Radiopharm. VL - 27 ID - Ozdemir2012 ER - TY - JOUR AU - Korga, A. AU - Ostrowska, M. AU - Iwan, M. AU - Herbet, M. AU - Dudka, J. PY - 2019 DA - 2019// TI - Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment JO - FEBS Open Bio. VL - 9 UR - https://doi.org/10.1002/2211-5463.12628 DO - 10.1002/2211-5463.12628 ID - Korga2019 ER - TY - JOUR AU - Chiou, J. F. AU - Tai, C. J. AU - Wang, Y. H. AU - Liu, T. Z. AU - Jen, Y. M. AU - Shiau, C. Y. PY - 2009 DA - 2009// TI - Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism JO - Cancer Biol Ther. VL - 8 UR - https://doi.org/10.4161/cbt.8.20.9436 DO - 10.4161/cbt.8.20.9436 ID - Chiou2009 ER - TY - JOUR AU - Lange, M. AU - Abhari, B. A. AU - Hinrichs, T. M. AU - Fulda, S. AU - Liese, J. PY - 2016 DA - 2016// TI - Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells JO - Biochem Pharmacol. VL - 118 UR - https://doi.org/10.1016/j.bcp.2016.08.011 DO - 10.1016/j.bcp.2016.08.011 ID - Lange2016 ER - TY - JOUR AU - Coriat, R. AU - Nicco, C. AU - Cheŕeau, C. AU - Mir, O. AU - Alexandre, J. AU - Ropert, S. PY - 2012 DA - 2012// TI - Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo JO - Mol Cancer Ther. VL - 11 UR - https://doi.org/10.1158/1535-7163.MCT-12-0093 DO - 10.1158/1535-7163.MCT-12-0093 ID - Coriat2012 ER - TY - JOUR AU - Feng, Y. X. AU - Wang, T. AU - Deng, Y. Z. AU - Yang, P. AU - Li, J. J. AU - Guan, D. X. PY - 2011 DA - 2011// TI - Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model JO - Hepatology. VL - 53 UR - https://doi.org/10.1002/hep.24075 DO - 10.1002/hep.24075 ID - Feng2011 ER -