Fig. 5
From: SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Sirt6 heterozygous deletion decreases OXPHOS and ATP/AMP ratio in MMTV-PyMT mammary tumors and in healthy mammary glands. a–d Mitochondrial complex activity (a–c) and energy status, expressed as ATP/AMP ratio (d), were measured in tumor masses that were isolated from 12-week-old MMTV-PyMT+/−; Sirt6+/+ (n = 5) and MMTV-PyMT+/−; Sirt6+/− (n = 4) mice. Data are presented as mean ± SD. ***P < 0.001. e–h Mitochondrial complex activity (e–g) and energy status, expressed as ATP/AMP ratio (h), were measured in the mammary glands that were isolated from 12-week-old Sirt6+/+ (n = 4) and Sirt6+/− (n = 4) mice. Data are presented as mean ± SD. **P < 0.01