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Fig. 2 | Cancer & Metabolism

Fig. 2

From: Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells

Fig. 2

DASA-58 treatment enhances extracellular acidification and lactate levels in BCa cell lines. a–c Online measurement of extracellular acidification using pH sensors embedded on the bottom of 24-well plates in MCF7 cells in response to DASA-58 (30 μM) alone or combined with either the ATP-synthase inhibitor oligomycin (5 μM), the mitochondrial complex one inhibitor metformin (5 mM), or the glycolytic inhibitor 2DG (5 mM) (a). Or in five different BCa cell lines in response to DASA-58 (30 μM and 60 μM) (b) or to TEPP-46 (30 μM, 60 μM, and 90 μM) c. d Fold change in extracellular lactate levels in five BCa cells lines in response to DASA-58 (30 μM) or to TEPP-46 (30 μM)

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Cancer & Metabolism

ISSN: 2049-3002