Fig. 2
From: The diversity and breadth of cancer cell fatty acid metabolism
Simple and complex lipid synthesis pathways. Fatty acyl-CoAs are used as building blocks for glycerolipids, glycerophospholipids, and ceramides and are attached to glycerol or sphingosine backbones through actions of acyltransferases and ceramide synthases. Likewise, acylceramides are generated from ceramide and fatty acyl-CoA. Fatty acids can be liberated through the actions of phospholipases, lysophospholipases, and ceramidases. CDase ceramidase, CerS ceramide synthase, DG diacylglycerol, DGAT diacylglycerol acyltransferase, DGK diacylglycerol kinase, FA-CoA fatty acyl-CoA, FA fatty acid, GPAT glycerol-3-phosphate acyltransferases, LPAAT lysophosphatidate acyl transferase, LPLAT lysophospholipid acyltransferase, LYPLA lysophospholipase A, MG monoacylglycerol, MGAT monoacylglycerol acyltransferase, PC phosphatidylcholine, PE phosphatidylethanolamine, PI phosphatidylinositol, PLA phospholipid lipase, PS phosphatidylserine, SPT1 serine palmitoyltransferase 1, TG triacylglycerols