TY - JOUR AU - Hyroššová, Petra AU - Aragó, Marc AU - Moreno-Felici, Juan AU - Fu, Xiarong AU - Mendez-Lucas, Andrés AU - García-Rovés, Pablo M. AU - Burgess, Shawn AU - Figueras, Agnès AU - Viñals, Francesc AU - Perales, Jose C. PY - 2021 DA - 2021/01/07 TI - PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner JO - Cancer & Metabolism SP - 1 VL - 9 IS - 1 AB - Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M; PCK2) is expressed in all cancer types examined and in neuroprogenitor cells. The gene is upregulated by amino acid limitation and ER-stress in an ATF4-dependent manner, and its activity modulates the PEP/Ca2+ signaling axis, providing clear arguments for a functional relationship with metabolic adaptations for cell survival. Despite its potential relevance to cancer metabolism, the mechanisms responsible for its pro-survival activity have not been completely elucidated. SN - 2049-3002 UR - https://doi.org/10.1186/s40170-020-00236-3 DO - 10.1186/s40170-020-00236-3 ID - Hyroššová2021 ER -