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Table 2 Clinical characteristics of the MGUS patients and their corresponding bolus and continuous infusion dosages of [13C5]-glutamine

From: In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

Patient #

Age

Sex

M-Spike

Isotype

Glutamine enrichment

MGUS #1c

52

F

0.4 g/dL

IgG lambda

5.21%

MGUS #2a

65

M

NQ; IgA, 476 mg/dL

IgA kappa

4.78%

MGUS #3c

71

M

1.2 g/dL

IgG lambda

4.61%

MGUS #4c

66

M

0.7 g/dL

IgG kappa

5.57%

MGUS #5b

69

M

1.4 g/dL

IgG lambda

3.49%

MGUS #6

48

M

1.2 g/dL

IgG kappa

4.90%

MGUS #7

56

F

1.2 g/dL

IgG kappa

5.84%

MGUS #8c

61

F

NQ; IgG, 867 mg/dL

IgG lambda

6.31%

MGUS #9c

71

M

NQ; kappa FLC, 47.5 mg/dL

Free kappa

6.25%

MGUS #10

67

F

0.6 g/dL

IgG kappa

5.56%

MGUS #11

56

F

NQ; IgA, 464 mg/dL

IgA kappa

6.00%

  1. NQ non-quantifiable
  2. aThe participant whose pre-malignant plasma cells from the marrow were unable to be analyzed for the isotopomers of malate by GC-MS
  3. bThe participant whose pre-malignant plasma cells from the marrow were unable to be analyzed for the isotopomers of glutamate by GC-MS
  4. cThe participant who did not have sufficient pre-malignant plasma cells from the marrow to undergo RNA sequencing